Comparison of unsatisfactory samples from conventional smear versus liquid-based cytology in uterine cervical cancer screening test

Hoiseon Jeong, Sung Ran Hong, Seoungc Wan Chae, So Young Jin, Hye Kyoung Yoon, Juhie Lee, Eun Kyung Kim, Sook Tai Ha, Sung Nam Kim, Eun Jung Park, Jong Jae Jung, Sun Hee Sung, Sung Chul Lim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories. Methods: Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis. Pap tests were classified according to the participating institution (commercial laboratory or general hospital) and the processing method (CS, ThinPrep, SurePath, or CellPrep). The causes of unsatisfactory results were classified as technical problems, scant cellularity, or complete obscuring factors. Results: A total of 38,956 Pap test results from eight general hospitals and three commercial laboratories were analyzed. The mean unsatisfactory rate of LBC was significantly lower than that of CS (1.26% and 3.31%, p =.018). In the LBC method, samples from general hospitals had lower unsatisfactory rates than those from commercial laboratories (0.65% vs 2.89%, p =.006). The reasons for unsatisfactory results were heterogeneous in CS. On the other hand, 66.2% of unsatisfactory results in LBC were due to the scant cellularity. Conclusions: Unsatisfactory rate of cervical cancer screening test results varies according to the institution and the processing method. LBC has a significantly lower unsatisfactory rate than CS.

Original languageEnglish
Pages (from-to)314-319
Number of pages6
JournalJournal of Pathology and Translational Medicine
Volume51
Issue number3
DOIs
StatePublished - 1 May 2017

Keywords

  • Cervical cytology
  • Conventional smear
  • Liquid-based cytology
  • Papanicolaou test
  • Unsatisfactory

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