Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01)

Yun Gyoo Lee, Eun Joo Kang, Bhumsuk Keam, Jin Hyuk Choi, Jin Soo Kim, Keon Uk Park, Kyoung Eun Lee, Keun Wook Lee, Min Kyoung Kim, Hee Kyung Ahn, Seong Hoon Shin, Hye Ryun Kim, Sung Bae Kim, Hyo Jung Kim, Hwan Jung Yun

Research output: Contribution to journalArticlepeer-review

Abstract

We aimed to compare treatment modalities and outcomes by gender in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We characterized the sex-specific differences and compared the overall survival (OS) between male and female patients in a multicenter cohort of LA-HNSCC. To minimize the observed confounding, propensity score matching was utilized. The study included 445 patients; 385 (86.5%) were men and 60 (13.5%) were women. In terms of age, smoking habits, drinking habits, and primary tumor locations, there was a significant imbalance in sex before the matching. Propensity score matching yielded 60 patient pairs, with no statistical difference between the sexes in terms of their characteristics. As for the treatment strategies, there were no significant differences between the sexes before (p = 0.260) and after (p = 0.585) the propensity score matching. When comparing the survival probabilities between the sexes, OS was not significantly different in the overall (HR 1.02; 95% CI 0.59–1.76; p = 0.938) and propensity-score-matched population (HR 1.46; 95% CI 0.68–3.17; p = 0.331). These results suggest that there was no difference in prognosis by gender in the treatment modalities and outcomes of LA-HNSCC in real-world practice.

Original languageEnglish
Article number471
JournalCancers
Volume15
Issue number2
DOIs
StatePublished - Jan 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • clinical outcome
  • gender
  • locally advanced head and neck squamous cell carcinoma

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