Comparison of the safety of seven iodinated contrast media

Jong Mi Seong, Nam Kyong Choi, Joongyub Lee, Yoosoo Chang, Ye Jee Kim, Bo Ram Yang, Xue Mei Jin, Ju Young Kim, Byung Joo Park

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


We aimed to determine the characteristic adverse events (AEs) of iodinated contrast media (IOCM) and to compare the safety profiles of different IOCM. This study used the database of AEs reports submitted by healthcare professionals from 15 Regional Pharmacovigilance Centers between June 24, 2009 and December 31, 2010 in Korea. All reports of IOCM, including iopromide, iohexol, iopamidol, iomeprol, ioversol, iobitridol and iodixanol, were analyzed. Safety profiles were compared between different IOCM at the system organ level using the proportional reporting ratio (PRR) and 95% confidence interval (95% CI). Among a total of 48,261 reports, 6,524 (13.5%) reports were related to the use of IOCM. Iopromide (45.5%), iohexol (16.9%), iopamidol (14.3%) and iomeprol (10.3%) were identified as frequently reported media. 'Platelet, bleeding & clotting disorders' (PRR, 29.6; 95%CI, 1.9-472.6) and 'urinary system disorders' (PRR, 22.3; 95% CI, 17.1-29.1) were more frequently reported for iodixanol than the other IOCM. In conclusion, the frequency of AEs by organ class was significantly different between individual media. These differences among different IOCM should be considered when selecting a medium among various IOCM and when monitoring patients during and after its use to ensure optimum usage and patient safety.

Original languageEnglish
Pages (from-to)1703-1710
Number of pages8
JournalJournal of Korean Medical Science
Issue number12
StatePublished - 2013

Bibliographical note

Publisher Copyright:
© 2013 The Korean Academy of Medical Sciences.


  • Adverse drug reaction reporting systems
  • Contrast media
  • Patient safety


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