Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study

Seung Soo Hong, Sung Sik Han, Wooil Kwon, Jin Young Jang, Hee Joon Kim, Chol Kyoon Cho, Keun Soo Ahn, Jae Do Yang, Youngmok Park, Seog Ki Min, Ju Ik Moon, Young Hoon Roh, Seung Eun Lee, Joon Seong Park, Sang Geol Kim, Chi Young Jeong, Jin Seok Heo, Ho Kyoung Hwang

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2 Scopus citations

Abstract

This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis–T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer.

Original languageEnglish
Article number2038
JournalCancers
Volume13
Issue number9
DOIs
StatePublished - 1 May 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Ampulla of Vater cancer
  • Pancreaticoduodenectomy
  • Transduodenal ampullectomy

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