Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study

Seung Soo Hong; Sung Sik Han; Wooil Kwon; Jin Young Jang; Hee Joon Kim; Chol Kyoon Cho; Keun Soo Ahn; Jae Do Yang; Youngmok Park; Seog Ki Min; Ju Ik Moon; Young Hoon Roh; Seung Eun Lee; Joon Seong Park; Sang Geol Kim; Chi Young Jeong; Jin Seok Heo; Ho Kyoung Hwang

doi:10.3390/cancers13092038

Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study

Seung Soo Hong, Sung Sik Han, Wooil Kwon, Jin Young Jang, Hee Joon Kim, Chol Kyoon Cho, Keun Soo Ahn, Jae Do Yang, Youngmok Park, Seog Ki Min, Ju Ik Moon, Young Hoon Roh, Seung Eun Lee, Joon Seong Park, Sang Geol Kim, Chi Young Jeong, Jin Seok Heo, Ho Kyoung Hwang

Department of Surgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis–T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer.

Original language	English
Article number	2038
Journal	Cancers
Volume	13
Issue number	9
DOIs	https://doi.org/10.3390/cancers13092038
State	Published - 1 May 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Ampulla of Vater cancer
Pancreaticoduodenectomy
Transduodenal ampullectomy

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Hong, S. S., Han, S. S., Kwon, W., Jang, J. Y., Kim, H. J., Cho, C. K., Ahn, K. S., Yang, J. D., Park, Y., Min, S. K., Moon, J. I., Roh, Y. H., Lee, S. E., Park, J. S., Kim, S. G., Jeong, C. Y., Heo, J. S., & Hwang, H. K. (2021). Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study. Cancers, 13(9), Article 2038. https://doi.org/10.3390/cancers13092038

@article{74f8e69a597f40b2b068b25b53c14b71,

title = "Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study",

abstract = "This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis–T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer.",

keywords = "Ampulla of Vater cancer, Pancreaticoduodenectomy, Transduodenal ampullectomy",

author = "Hong, {Seung Soo} and Han, {Sung Sik} and Wooil Kwon and Jang, {Jin Young} and Kim, {Hee Joon} and Cho, {Chol Kyoon} and Ahn, {Keun Soo} and Yang, {Jae Do} and Youngmok Park and Min, {Seog Ki} and Moon, {Ju Ik} and Roh, {Young Hoon} and Lee, {Seung Eun} and Park, {Joon Seong} and Kim, {Sang Geol} and Jeong, {Chi Young} and Heo, {Jin Seok} and Hwang, {Ho Kyoung}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

day = "1",

doi = "10.3390/cancers13092038",

language = "English",

volume = "13",

journal = "Cancers",

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Hong, SS, Han, SS, Kwon, W, Jang, JY, Kim, HJ, Cho, CK, Ahn, KS, Yang, JD, Park, Y, Min, SK, Moon, JI, Roh, YH, Lee, SE, Park, JS, Kim, SG, Jeong, CY, Heo, JS & Hwang, HK 2021, 'Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study', Cancers, vol. 13, no. 9, 2038. https://doi.org/10.3390/cancers13092038

TY - JOUR

T1 - Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer

T2 - Korean multicenter study

AU - Hong, Seung Soo

AU - Han, Sung Sik

AU - Kwon, Wooil

AU - Jang, Jin Young

AU - Kim, Hee Joon

AU - Cho, Chol Kyoon

AU - Ahn, Keun Soo

AU - Yang, Jae Do

AU - Park, Youngmok

AU - Min, Seog Ki

AU - Moon, Ju Ik

AU - Roh, Young Hoon

AU - Lee, Seung Eun

AU - Park, Joon Seong

AU - Kim, Sang Geol

AU - Jeong, Chi Young

AU - Heo, Jin Seok

AU - Hwang, Ho Kyoung

PY - 2021/5/1

Y1 - 2021/5/1

N2 - This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis–T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer.

AB - This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis–T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer.

KW - Ampulla of Vater cancer

KW - Pancreaticoduodenectomy

KW - Transduodenal ampullectomy

UR - http://www.scopus.com/inward/record.url?scp=85104557984&partnerID=8YFLogxK

U2 - 10.3390/cancers13092038

DO - 10.3390/cancers13092038

M3 - Article

AN - SCOPUS:85104557984

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 9

M1 - 2038

ER -

Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study

Abstract

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Keywords

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