Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis

Won Jung Koh; Seung Heon Lee; Young Ae Kang; Chang Hoon Lee; Jae Chol Choi; Jae Ho Lee; Seung Hun Jang; Kwang Ha Yoo; Ki Hwan Jung; Ki Uk Kim; Sang Bong Choi; Yon Ju Ryu; Kyung Chan Kim; Soojung Um; Yong Soo Kwon; Yee Hyung Kim; Won Il Choi; Kyeongman Jeon; Yong Il Hwang; Se Joong Kim; Young Seok Lee; Eun Young Heo; Juhee Lee; Yeo WoonKi; Tae Sun Shim; Jae Joon Yim

doi:10.1164/rccm.201303-0604OC

Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis

Won Jung Koh
, Seung Heon Lee
, Young Ae Kang
, Chang Hoon Lee
, Jae Chol Choi
, Jae Ho Lee
, Seung Hun Jang
, Kwang Ha Yoo
, Ki Hwan Jung
, Ki Uk Kim
, Sang Bong Choi
, Yon Ju Ryu
, Kyung Chan Kim
, Soojung Um
, Yong Soo Kwon
, Yee Hyung Kim
, Won Il Choi
, Kyeongman Jeon
, Yong Il Hwang
, Se Joong Kim

Young Seok Lee, Eun Young Heo, Juhee Lee, Yeo WoonKi, Tae Sun Shim, Jae Joon Yim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Measurements and Main Results: At 3 months of treatment, 68 (88.3%) of the 77 patients in the LFX group and 67 (90.5%) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95% confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7%) in the LFX group and four (5.2%) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).

Original language	English
Pages (from-to)	858-864
Number of pages	7
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	188
Issue number	7
DOIs	https://doi.org/10.1164/rccm.201303-0604OC
State	Published - 1 Oct 2013

Keywords

Fluoroquinolone
Levofloxacin
Moxifloxacin
Multidrug-resistant tuberculosis

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Koh, W. J., Lee, S. H., Kang, Y. A., Lee, C. H., Choi, J. C., Lee, J. H., Jang, S. H., Yoo, K. H., Jung, K. H., Kim, K. U., Choi, S. B., Ryu, Y. J., Kim, K. C., Um, S., Kwon, Y. S., Kim, Y. H., Choi, W. I., Jeon, K., Hwang, Y. I., ... Yim, J. J. (2013). Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis. American Journal of Respiratory and Critical Care Medicine, 188(7), 858-864. https://doi.org/10.1164/rccm.201303-0604OC

@article{f15d044abafa46fa99f48c2910f7c4a5,

title = "Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis",

abstract = "Measurements and Main Results: At 3 months of treatment, 68 (88.3\%) of the 77 patients in the LFX group and 67 (90.5\%) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95\% confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7\%) in the LFX group and four (5.2\%) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).",

keywords = "Fluoroquinolone, Levofloxacin, Moxifloxacin, Multidrug-resistant tuberculosis",

author = "Koh, \{Won Jung\} and Lee, \{Seung Heon\} and Kang, \{Young Ae\} and Lee, \{Chang Hoon\} and Choi, \{Jae Chol\} and Lee, \{Jae Ho\} and Jang, \{Seung Hun\} and Yoo, \{Kwang Ha\} and Jung, \{Ki Hwan\} and Kim, \{Ki Uk\} and Choi, \{Sang Bong\} and Ryu, \{Yon Ju\} and Kim, \{Kyung Chan\} and Soojung Um and Kwon, \{Yong Soo\} and Kim, \{Yee Hyung\} and Choi, \{Won Il\} and Kyeongman Jeon and Hwang, \{Yong Il\} and Kim, \{Se Joong\} and Lee, \{Young Seok\} and Heo, \{Eun Young\} and Juhee Lee and Yeo WoonKi and Shim, \{Tae Sun\} and Yim, \{Jae Joon\}",

year = "2013",

month = oct,

day = "1",

doi = "10.1164/rccm.201303-0604OC",

language = "English",

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Koh, WJ, Lee, SH, Kang, YA, Lee, CH, Choi, JC, Lee, JH, Jang, SH, Yoo, KH, Jung, KH, Kim, KU, Choi, SB, Ryu, YJ, Kim, KC, Um, S, Kwon, YS, Kim, YH, Choi, WI, Jeon, K, Hwang, YI, Kim, SJ, Lee, YS, Heo, EY, Lee, J, WoonKi, Y, Shim, TS & Yim, JJ 2013, 'Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis', American Journal of Respiratory and Critical Care Medicine, vol. 188, no. 7, pp. 858-864. https://doi.org/10.1164/rccm.201303-0604OC

TY - JOUR

T1 - Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis

AU - Koh, Won Jung

AU - Lee, Seung Heon

AU - Kang, Young Ae

AU - Lee, Chang Hoon

AU - Choi, Jae Chol

AU - Lee, Jae Ho

AU - Jang, Seung Hun

AU - Yoo, Kwang Ha

AU - Jung, Ki Hwan

AU - Kim, Ki Uk

AU - Choi, Sang Bong

AU - Ryu, Yon Ju

AU - Kim, Kyung Chan

AU - Um, Soojung

AU - Kwon, Yong Soo

AU - Kim, Yee Hyung

AU - Choi, Won Il

AU - Jeon, Kyeongman

AU - Hwang, Yong Il

AU - Kim, Se Joong

AU - Lee, Young Seok

AU - Heo, Eun Young

AU - Lee, Juhee

AU - WoonKi, Yeo

AU - Shim, Tae Sun

AU - Yim, Jae Joon

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Measurements and Main Results: At 3 months of treatment, 68 (88.3%) of the 77 patients in the LFX group and 67 (90.5%) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95% confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7%) in the LFX group and four (5.2%) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).

AB - Measurements and Main Results: At 3 months of treatment, 68 (88.3%) of the 77 patients in the LFX group and 67 (90.5%) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95% confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7%) in the LFX group and four (5.2%) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).

KW - Fluoroquinolone

KW - Levofloxacin

KW - Moxifloxacin

KW - Multidrug-resistant tuberculosis

UR - https://www.scopus.com/pages/publications/84886289933

U2 - 10.1164/rccm.201303-0604OC

DO - 10.1164/rccm.201303-0604OC

M3 - Article

C2 - 23927582

AN - SCOPUS:84886289933

SN - 1073-449X

VL - 188

SP - 858

EP - 864

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 7

ER -

Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis

Abstract

Keywords

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