Comparison of hemodynamic response to tracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture under general anesthesia: A randomized controlled trial comparing fentanyl and oxycodone

Yeon Sil Lee, Chong Wha Baek, Dong Rim Kim, Hyun Kang, Geun Joo Choi, Yong Hee Park, Won joong Kim, Yong Hun Jung, Young Cheol Woo

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13 Scopus citations

Abstract

Background: The present study aimed to compare the intravenous bolus effect of oxycodone and fentanyl on hemodynamic response after endotracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture. Methods: In this prospective randomized double-blinded study, 64 patients undergoing closed reduction of nasal bone fracture were randomized into one of two groups: the fentanyl group (Group F) or the oxycodone group (Group O). Each drug (fentanyl 2 mcg/kg in Group F and oxycodone 0.2 mg/kg in Group O) was administered prior to the induction of general anesthesia. Hemodynamic changes after endotracheal intubation and postoperative pain were then measured in both groups. Results: There was no significant difference in the change in mean arterial pressure and heart rate between pre-induction and post-intubation in both Groups F and O (P>0.05). Postoperative pain in Group O was milder than that in Group F (P<0.001); however, time to awakening from the end of operation was shorter in Group F (P=0.012). Conclusion: In patients undergoing closed reduction of nasal bone fracture, oxycodone attenuates hemodynamic response to endotracheal intubation similar to fentanyl. However, oxycodone is more effective than fentanyl in improving postoperative pain. Trial registration: Clinical Research Information Service (Trial registry number: KCT0001153) on 3 July, 2014

Original languageEnglish
Article number115
JournalBMC Anesthesiology
Volume16
Issue number1
DOIs
StatePublished - 17 Nov 2016

Keywords

  • Fentanyl
  • Hemodynamics
  • Intubation
  • Oxycodone
  • Postoperative pain

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