@article{f3f28c1467884b81aa0af74d80d86e49,
title = "Comparison of early and late Pneumocystis jirovecii Pneumonia in kidney transplant patients: the Korean Organ Transplantation Registry (KOTRY) Study",
abstract = "Late Pneumocystis jirovecii pneumonia (PJP) is not rare in the era of universal prophylaxis after kidney transplantation. We aimed to determine the nationwide status of PJP prophylaxis in Korea and compare the incidence, risk factors, and outcomes of early and late PJP using data from the Korean Organ Transplantation Registry (KOTRY), a nationwide Korean transplant cohort. We conducted a retrospective analysis using data of 4,839 kidney transplant patients from KOTRY between 2014 and 2018, excluding patients who received multi-organ transplantation or were under 18 years old. Cox regression analysis was performed to determine risk factors for early and late PJP. A total of 50 patients developed PJP. The number of patients who developed PJP was same between onset before 6 months and onsets after 6 months. There were no differences in the rate, duration, or dose of PJP prophylaxis between early and late PJP. Desensitization, higher tacrolimus dose at discharge, and acute rejection were associated with early PJP. In late PJP, old age as well as acute rejection were significant risk factors. In conclusion late PJP is as common and risky as early PJP and requires individualized risk-based prophylaxis, such as prolonged prophylaxis for old patients with a history of rejection.",
author = "{KOTRY study group} and Gongmyung Lee and Koo, {Tai Yeon} and Kim, {Hyung Woo} and Lee, {Dong Ryeol} and Lee, {Dong Won} and Jieun Oh and Kim, {Beom Seok} and Kim, {Myoung Soo} and Jaeseok Yang and Kim, {Myoung Soo} and Jaeseok Yang and Kong, {Jin Min} and Kwon, {Oh Jung} and Kim, {Deok Gie} and Jung, {Cheol Woong} and Kim, {Yeong Hoon} and Kim, {Joong Kyung} and Kim, {Chan Duck} and Min, {Ji Won} and Sik Lee and Park, {Yeon Ho} and Park, {Jae Berm} and Park, {Jung Hwan} and Park, {Jong Won} and Ban, {Tae Hyun} and Song, {Sang Heon} and Song, {Seung Hwan} and Shin, {Ho Sik} and Yang, {Chul Woo} and Yoon, {Hye Eun} and Lee, {Kang Wook} and Lee, {Dong Ryeol} and Lee, {Dong Won} and Jieun Oh and Lee, {Sang Ho} and Lee, {Su Hyung} and Lee, {Yu Ho} and Lee, {Jung Pyo} and Lee, {Jeong Hoon} and Jeon, {Jin Seok} and Heungman Jun and Jeong, {Kyung Hwan} and Chung, {Ku Yong} and Lee, {Jong Soo} and Ki, {Ju Man} and Chae, {Dong Wan} and Choi, {Soo Jin Na} and Sung Shin and Seungyeup Han and Huh, {Kyu Ha}",
note = "Funding Information: This research was supported by a fund (2014-ER6301-00, 2014-ER6301-01, 2014-ER6301-02, 2017-ER6301-00, and 2017-ER6301-01) by Research of Korea Centers for Disease Control and Prevention. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41598-022-14580-5",
language = "English",
volume = "12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}