Comparative studies of adriamycin and 28-Deacetyl sendanin on in vitro growth inhibition of human cancer cell lines

Hwan Mook Kim, Goo Taeg Oh, Sang Bae Han, Dong Ho Hong, Bang Yeon Hwang, Young Ho Kim, Jung Joon Lee

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The limonoid compound (28-deacetyl sendanin) isolated from the fruit of Melia toosendan SIEB. et ZUCC. was evaluated on anticancer activity. According to a standard in vitro cytotoxicity assay, eight human cancer cell lines and SRB assay were introduced for present evaluation. As a positive standard, adriamycin was tested in parallel The cell lines were originated from six different organs. In view of dose-response profiles to 28-deacetyl sendanin, the most sensitive cells were SF-539 and PC-3 which were derived from CNS and prostate, respectively. In contrast, all the cell lines responded similarly to adriamycin to give rise to nearly identical dose-response profiles. By comparison of Gl50 between 28-deacetyl sendanin and adriamycin, six cell lines were more sensitive to 28-deacetyl sendanin and two were more resistant. As a result 28-deacetyl sendanin had more sensitive and selective inhibitory effects on in vitro growth of human cancer cell lines in a comparison with adriamycin.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalArchives of Pharmacal Research
Volume17
Issue number2
DOIs
StatePublished - Apr 1994

Keywords

  • 28-deacetyl sendanin
  • Adriamycin
  • Anticancer
  • Limonoid
  • Melia toosendan SIEB. et ZUCC.
  • SRB assay
  • human cancer cells

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