Combined outer volume suppression and T2 preparation sequence for coronary angiography

Jieying Luo, Nii Okai Addy, R. Reeve Ingle, Brian A. Hargreaves, Bob S. Hu, Dwight G. Nishimura, Taehoon Shin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose To develop a magnetization preparation sequence for simultaneous outer volume suppression (OVS) and T2 weighting in whole-heart coronary magnetic resonance angiography. Methods A combined OVS and T2 preparation sequence (OVS-T2 Prep) was designed with a nonselective adiabatic 90 tipdown pulse, two adiabatic 180 refocusing pulses, and a 2D spiral -90 tipup pulse. The OVS-T2 Prep preserves the magnetization inside an elliptic cylinder with T2 weighting, while saturating the magnetization outside the cylinder. Its performance was tested on phantoms and on 13 normal subjects with coronary magnetic resonance angiography using 3D cones trajectories. Results Phantom studies showed expected T2-dependent signal amplitude in the spatial passband and suppressed signal in the spatial stopband. In vivo studies with full-field-of-view cones yielded a passband-to-stopband signal ratio of 3.18 ± 0.77 and blood-myocardium contrast-to-noise ratio enhancement by a factor of 1.43 ± 0.20 (P < 0.001). In vivo studies with reduced-field-of-view cones showed that OVS-T2 Prep well suppressed the aliasing artifacts, as supported by significantly reduced signal in the regions with no tissues compared to the images acquired without preparation (P < 0.0001). Conclusion OVS-T2 Prep is a compact sequence that can accelerate coronary magnetic resonance angiography by suppressing signals from tissues surrounding the heart while simultaneously enhancing the blood-myocardium contrast. Magn Reson Med 74:1632-1639, 2015.

Original languageEnglish
Pages (from-to)1632-1639
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number6
StatePublished - 1 Dec 2015

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.


  • T Prep
  • cones imaging
  • coronary MR angiography
  • outer volume suppression
  • radiofrequency pulse design


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