Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses

Jung Yeon Moon; Kyung Eun Lee; Byung Chul Chang; Eurim Jeong; Hotcherl Jeong; Hye Sun Gwak

doi:10.1097/FPC.0000000000000103

Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses

Jung Yeon Moon, Kyung Eun Lee, Byung Chul Chang, Eurim Jeong, Hotcherl Jeong, Hye Sun Gwak

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A possible association between the combination of genetic variations in hepatocyte nuclear factor 4α (HNF4α) and constitutive androstane receptor (CAR) and the stable doses of warfarin was examined in patients from the Ewha-Severance Treatment (EAST) Group of Warfarin. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; the vitamin K epoxide reductase complex 1 (VKORC1) genotype accounted for 29.6%, the cytochrome P450 (CYP) 2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4α (rs2501873/rs3212198) for 1.7%. Our results showed that the combination of CAR and HNF4α genotypes could be determinants of stable warfarin doses.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Pharmacogenetics and Genomics
Volume	25
Issue number	1
DOIs	https://doi.org/10.1097/FPC.0000000000000103
State	Published - 14 Jan 2015

Bibliographical note

Publisher Copyright:
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Keywords

CYP2C9
Constitutive androstane receptor
Hepatocyte nuclear factor 4α
Transcription factor
Warfarin

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10.1097/FPC.0000000000000103

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title = "Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses",

abstract = "A possible association between the combination of genetic variations in hepatocyte nuclear factor 4α (HNF4α) and constitutive androstane receptor (CAR) and the stable doses of warfarin was examined in patients from the Ewha-Severance Treatment (EAST) Group of Warfarin. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; the vitamin K epoxide reductase complex 1 (VKORC1) genotype accounted for 29.6%, the cytochrome P450 (CYP) 2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4α (rs2501873/rs3212198) for 1.7%. Our results showed that the combination of CAR and HNF4α genotypes could be determinants of stable warfarin doses.",

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AU - Moon, Jung Yeon

AU - Lee, Kyung Eun

AU - Chang, Byung Chul

AU - Jeong, Eurim

AU - Jeong, Hotcherl

AU - Gwak, Hye Sun

PY - 2015/1/14

Y1 - 2015/1/14

N2 - A possible association between the combination of genetic variations in hepatocyte nuclear factor 4α (HNF4α) and constitutive androstane receptor (CAR) and the stable doses of warfarin was examined in patients from the Ewha-Severance Treatment (EAST) Group of Warfarin. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; the vitamin K epoxide reductase complex 1 (VKORC1) genotype accounted for 29.6%, the cytochrome P450 (CYP) 2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4α (rs2501873/rs3212198) for 1.7%. Our results showed that the combination of CAR and HNF4α genotypes could be determinants of stable warfarin doses.

AB - A possible association between the combination of genetic variations in hepatocyte nuclear factor 4α (HNF4α) and constitutive androstane receptor (CAR) and the stable doses of warfarin was examined in patients from the Ewha-Severance Treatment (EAST) Group of Warfarin. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; the vitamin K epoxide reductase complex 1 (VKORC1) genotype accounted for 29.6%, the cytochrome P450 (CYP) 2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4α (rs2501873/rs3212198) for 1.7%. Our results showed that the combination of CAR and HNF4α genotypes could be determinants of stable warfarin doses.

KW - CYP2C9

KW - Constitutive androstane receptor

KW - Hepatocyte nuclear factor 4α

KW - Transcription factor

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IS - 1

ER -

Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses

Abstract

Bibliographical note

Keywords

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