Combined Chemoradiotherapy-induced Weight Loss Decreases Survival in Locally Advanced Non-small Cell Lung Cancer Patients

Yi Jun Kim; Changhoon Song; Keun Yong Eom; In Ah Kim; Jae Sung Kim

doi:10.21873/invivo.11564

Combined Chemoradiotherapy-induced Weight Loss Decreases Survival in Locally Advanced Non-small Cell Lung Cancer Patients

Yi Jun Kim, Changhoon Song, Keun Yong Eom, In Ah Kim, Jae Sung Kim

Department of Environmental Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background/Aim: The aim of the study was to investigate the prognostic impact and predictors of weight loss during definitive radiotherapy in non-small cell lung cancer (NSCLC) patients. Patients and Methods: A total of 125 NSCLC patients (2003-2016) who had received definitive radiotherapy were included in the study. Multivariate analyses were performed to estimate prognostic values. Predictors for weight loss were analyzed. Results: The median survival of patients with weight loss (>5%) during radiotherapy and for those without any significant weight loss was 15.6 and 33 months, respectively (p=0.015). Non-intensity modulated radiotherapy (IMRT) technique was the only factor associated with weight loss (p=0.039). Weight loss was a poor prognostic factor for overall survival (OS) (hazard ratio [HR] 2.072, p=0.018), and IMRT was a favorable prognostic factor (HR=0.192, p=0.029). Conclusion: During definitive radiotherapy, weight loss of >5% resulted in decreased OS rate in locally advanced NSCLC. IMRT might increase OS rate by minimizing weight loss.

Original language	English
Pages (from-to)	955-961
Number of pages	7
Journal	In Vivo
Volume	33
Issue number	3
DOIs	https://doi.org/10.21873/invivo.11564
State	Published - May 2019

Bibliographical note

Funding Information:
This study was supported by 2017 Young Medical Science Researcher Grants from Ewha Womans University College of Medicine. The authors declare that they have no conflict of interest.

Publisher Copyright:
© 2019 International Institute of Anticancer Research. All rights reserved.

Keywords

Body weight
Definitive radiotherapy
IMRT
Non-small cell lung cancer

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10.21873/invivo.11564

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@article{cb689d5ac62a43d1bc6dc792dab45c9e,

title = "Combined Chemoradiotherapy-induced Weight Loss Decreases Survival in Locally Advanced Non-small Cell Lung Cancer Patients",

abstract = "Background/Aim: The aim of the study was to investigate the prognostic impact and predictors of weight loss during definitive radiotherapy in non-small cell lung cancer (NSCLC) patients. Patients and Methods: A total of 125 NSCLC patients (2003-2016) who had received definitive radiotherapy were included in the study. Multivariate analyses were performed to estimate prognostic values. Predictors for weight loss were analyzed. Results: The median survival of patients with weight loss (>5%) during radiotherapy and for those without any significant weight loss was 15.6 and 33 months, respectively (p=0.015). Non-intensity modulated radiotherapy (IMRT) technique was the only factor associated with weight loss (p=0.039). Weight loss was a poor prognostic factor for overall survival (OS) (hazard ratio [HR] 2.072, p=0.018), and IMRT was a favorable prognostic factor (HR=0.192, p=0.029). Conclusion: During definitive radiotherapy, weight loss of >5% resulted in decreased OS rate in locally advanced NSCLC. IMRT might increase OS rate by minimizing weight loss.",

keywords = "Body weight, Definitive radiotherapy, IMRT, Non-small cell lung cancer",

author = "Kim, {Yi Jun} and Changhoon Song and Eom, {Keun Yong} and Kim, {In Ah} and Kim, {Jae Sung}",

note = "Funding Information: This study was supported by 2017 Young Medical Science Researcher Grants from Ewha Womans University College of Medicine. The authors declare that they have no conflict of interest. Publisher Copyright: {\textcopyright} 2019 International Institute of Anticancer Research. All rights reserved.",

year = "2019",

month = may,

doi = "10.21873/invivo.11564",

language = "English",

volume = "33",

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publisher = "International Institute of Anticancer Research",

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AU - Kim, Yi Jun

AU - Song, Changhoon

AU - Eom, Keun Yong

AU - Kim, In Ah

AU - Kim, Jae Sung

N1 - Funding Information: This study was supported by 2017 Young Medical Science Researcher Grants from Ewha Womans University College of Medicine. The authors declare that they have no conflict of interest. Publisher Copyright: © 2019 International Institute of Anticancer Research. All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - Background/Aim: The aim of the study was to investigate the prognostic impact and predictors of weight loss during definitive radiotherapy in non-small cell lung cancer (NSCLC) patients. Patients and Methods: A total of 125 NSCLC patients (2003-2016) who had received definitive radiotherapy were included in the study. Multivariate analyses were performed to estimate prognostic values. Predictors for weight loss were analyzed. Results: The median survival of patients with weight loss (>5%) during radiotherapy and for those without any significant weight loss was 15.6 and 33 months, respectively (p=0.015). Non-intensity modulated radiotherapy (IMRT) technique was the only factor associated with weight loss (p=0.039). Weight loss was a poor prognostic factor for overall survival (OS) (hazard ratio [HR] 2.072, p=0.018), and IMRT was a favorable prognostic factor (HR=0.192, p=0.029). Conclusion: During definitive radiotherapy, weight loss of >5% resulted in decreased OS rate in locally advanced NSCLC. IMRT might increase OS rate by minimizing weight loss.

AB - Background/Aim: The aim of the study was to investigate the prognostic impact and predictors of weight loss during definitive radiotherapy in non-small cell lung cancer (NSCLC) patients. Patients and Methods: A total of 125 NSCLC patients (2003-2016) who had received definitive radiotherapy were included in the study. Multivariate analyses were performed to estimate prognostic values. Predictors for weight loss were analyzed. Results: The median survival of patients with weight loss (>5%) during radiotherapy and for those without any significant weight loss was 15.6 and 33 months, respectively (p=0.015). Non-intensity modulated radiotherapy (IMRT) technique was the only factor associated with weight loss (p=0.039). Weight loss was a poor prognostic factor for overall survival (OS) (hazard ratio [HR] 2.072, p=0.018), and IMRT was a favorable prognostic factor (HR=0.192, p=0.029). Conclusion: During definitive radiotherapy, weight loss of >5% resulted in decreased OS rate in locally advanced NSCLC. IMRT might increase OS rate by minimizing weight loss.

KW - Body weight

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KW - Non-small cell lung cancer

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Combined Chemoradiotherapy-induced Weight Loss Decreases Survival in Locally Advanced Non-small Cell Lung Cancer Patients

Abstract

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