Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation

Ji Yup Kim; Seulbi Kim; Sol Han; Sang Yeong Han; Cláudia P. Passos; Jeongyeon Seo; Hojae Lee; Eunhye K. Kang; João F. Mano; Manuel A. Coimbra; Ji Hun Park; Insung S. Choi

doi:10.1002/cnma.202000004

Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation

Ji Yup Kim, Seulbi Kim, Sol Han, Sang Yeong Han, Cláudia P. Passos, Jeongyeon Seo, Hojae Lee, Eunhye K. Kang, João F. Mano, Manuel A. Coimbra, Ji Hun Park, Insung S. Choi

Department of Science Education

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The melanoidin from soluble coffee is utilized as a material-independent, multipurpose coating material. Instantaneous complexation of the coffee melanoidin (CM) with ferric ion (Fe³⁺) leads to surface-adhesive aggregates, inducing sequential film deposition. Various chemical groups of the CM also allow for post-functionalizations of the CM film, including surface-initiated, ring-opening polymerization and bioinspired silicification. In addition, the CM-based coating is applied to single-cell nanoencapsulation with a strategy of biphasic interfacial reactions. The method is highly cytocompatible (viability >98%), and the CM shell is cytoprotective against lytic enzymes. The coated cells inherit the characterictics of the CM, such as post-functionalizability and antioxidant property. Considering that surface-coating technologies with cytocompatible natural polymers have widely been used for engineering bioentities, the CM-based coating strategy would provide an advanced option for biomedical applications.

Original language	English
Pages (from-to)	379-385
Number of pages	7
Journal	ChemNanoMat
Volume	6
Issue number	3
DOIs	https://doi.org/10.1002/cnma.202000004
State	Published - 1 Mar 2020

Bibliographical note

Funding Information:
This work was supported by the Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2009-0082580), and developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. And we would like to thank the UA and FCT/MCT for the financial support for the QOPNA research Unit (FCT UID/QUI/00062/2019) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. Cl?udia Passos contract (CEECIND/01873/2017) was supported by FCT.

Publisher Copyright:
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

carbohydrates
cell encapsulation
coffee melanoidin
film formation
surface engineering

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10.1002/cnma.202000004

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@article{9aea244e0fca4cf79dd65a735769d4b6,

title = "Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation",

abstract = "The melanoidin from soluble coffee is utilized as a material-independent, multipurpose coating material. Instantaneous complexation of the coffee melanoidin (CM) with ferric ion (Fe3+) leads to surface-adhesive aggregates, inducing sequential film deposition. Various chemical groups of the CM also allow for post-functionalizations of the CM film, including surface-initiated, ring-opening polymerization and bioinspired silicification. In addition, the CM-based coating is applied to single-cell nanoencapsulation with a strategy of biphasic interfacial reactions. The method is highly cytocompatible (viability >98%), and the CM shell is cytoprotective against lytic enzymes. The coated cells inherit the characterictics of the CM, such as post-functionalizability and antioxidant property. Considering that surface-coating technologies with cytocompatible natural polymers have widely been used for engineering bioentities, the CM-based coating strategy would provide an advanced option for biomedical applications.",

keywords = "carbohydrates, cell encapsulation, coffee melanoidin, film formation, surface engineering",

author = "Kim, {Ji Yup} and Seulbi Kim and Sol Han and Han, {Sang Yeong} and Passos, {Cl{\'a}udia P.} and Jeongyeon Seo and Hojae Lee and Kang, {Eunhye K.} and Mano, {Jo{\~a}o F.} and Coimbra, {Manuel A.} and Park, {Ji Hun} and Choi, {Insung S.}",

note = "Funding Information: This work was supported by the Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2009-0082580), and developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. And we would like to thank the UA and FCT/MCT for the financial support for the QOPNA research Unit (FCT UID/QUI/00062/2019) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. Cl?udia Passos contract (CEECIND/01873/2017) was supported by FCT. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2020",

month = mar,

day = "1",

doi = "10.1002/cnma.202000004",

language = "English",

volume = "6",

pages = "379--385",

journal = "ChemNanoMat",

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T2 - Application to Single-Cell Nanoencapsulation

AU - Kim, Ji Yup

AU - Kim, Seulbi

AU - Han, Sol

AU - Han, Sang Yeong

AU - Passos, Cláudia P.

AU - Seo, Jeongyeon

AU - Lee, Hojae

AU - Kang, Eunhye K.

AU - Mano, João F.

AU - Coimbra, Manuel A.

AU - Park, Ji Hun

AU - Choi, Insung S.

N1 - Funding Information: This work was supported by the Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2009-0082580), and developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. And we would like to thank the UA and FCT/MCT for the financial support for the QOPNA research Unit (FCT UID/QUI/00062/2019) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. Cl?udia Passos contract (CEECIND/01873/2017) was supported by FCT. Publisher Copyright: © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2020/3/1

Y1 - 2020/3/1

N2 - The melanoidin from soluble coffee is utilized as a material-independent, multipurpose coating material. Instantaneous complexation of the coffee melanoidin (CM) with ferric ion (Fe3+) leads to surface-adhesive aggregates, inducing sequential film deposition. Various chemical groups of the CM also allow for post-functionalizations of the CM film, including surface-initiated, ring-opening polymerization and bioinspired silicification. In addition, the CM-based coating is applied to single-cell nanoencapsulation with a strategy of biphasic interfacial reactions. The method is highly cytocompatible (viability >98%), and the CM shell is cytoprotective against lytic enzymes. The coated cells inherit the characterictics of the CM, such as post-functionalizability and antioxidant property. Considering that surface-coating technologies with cytocompatible natural polymers have widely been used for engineering bioentities, the CM-based coating strategy would provide an advanced option for biomedical applications.

AB - The melanoidin from soluble coffee is utilized as a material-independent, multipurpose coating material. Instantaneous complexation of the coffee melanoidin (CM) with ferric ion (Fe3+) leads to surface-adhesive aggregates, inducing sequential film deposition. Various chemical groups of the CM also allow for post-functionalizations of the CM film, including surface-initiated, ring-opening polymerization and bioinspired silicification. In addition, the CM-based coating is applied to single-cell nanoencapsulation with a strategy of biphasic interfacial reactions. The method is highly cytocompatible (viability >98%), and the CM shell is cytoprotective against lytic enzymes. The coated cells inherit the characterictics of the CM, such as post-functionalizability and antioxidant property. Considering that surface-coating technologies with cytocompatible natural polymers have widely been used for engineering bioentities, the CM-based coating strategy would provide an advanced option for biomedical applications.

KW - carbohydrates

KW - cell encapsulation

KW - coffee melanoidin

KW - film formation

KW - surface engineering

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DO - 10.1002/cnma.202000004

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IS - 3

ER -

Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation

Abstract

Bibliographical note

Keywords

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