@article{9aea244e0fca4cf79dd65a735769d4b6,
title = "Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation",
abstract = "The melanoidin from soluble coffee is utilized as a material-independent, multipurpose coating material. Instantaneous complexation of the coffee melanoidin (CM) with ferric ion (Fe3+) leads to surface-adhesive aggregates, inducing sequential film deposition. Various chemical groups of the CM also allow for post-functionalizations of the CM film, including surface-initiated, ring-opening polymerization and bioinspired silicification. In addition, the CM-based coating is applied to single-cell nanoencapsulation with a strategy of biphasic interfacial reactions. The method is highly cytocompatible (viability >98%), and the CM shell is cytoprotective against lytic enzymes. The coated cells inherit the characterictics of the CM, such as post-functionalizability and antioxidant property. Considering that surface-coating technologies with cytocompatible natural polymers have widely been used for engineering bioentities, the CM-based coating strategy would provide an advanced option for biomedical applications.",
keywords = "carbohydrates, cell encapsulation, coffee melanoidin, film formation, surface engineering",
author = "Kim, {Ji Yup} and Seulbi Kim and Sol Han and Han, {Sang Yeong} and Passos, {Cl{\'a}udia P.} and Jeongyeon Seo and Hojae Lee and Kang, {Eunhye K.} and Mano, {Jo{\~a}o F.} and Coimbra, {Manuel A.} and Park, {Ji Hun} and Choi, {Insung S.}",
note = "Funding Information: This work was supported by the Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2009-0082580), and developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. And we would like to thank the UA and FCT/MCT for the financial support for the QOPNA research Unit (FCT UID/QUI/00062/2019) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. Cl?udia Passos contract (CEECIND/01873/2017) was supported by FCT. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = mar,
day = "1",
doi = "10.1002/cnma.202000004",
language = "English",
volume = "6",
pages = "379--385",
journal = "ChemNanoMat",
issn = "2199-692X",
publisher = "Wiley-VCH Verlag",
number = "3",
}