Abstract
Purpose: While MP2RAGE shows the potential to generate B1 insensitive T1 contrast, the long TR of MP2RAGE (≥6 s at 7 T) is essential to provide the large dynamic range of apparent T1 relaxation for dual inversion time acquisitions. We present a 2 direction (2D) accelerated MP2RAGE, which provides an increased flip angle while maintaining similar dynamic recovery as 1D accelerated MP2RAGE. Method: Simulations were conducted to optimize 2D accelerated MP2RAGE parameters and healthy subjects were scanned with 1D and 2D accelerated MP2RAGE at 7 T. Images were compared visually and contrast to noise (CNR) between brain tissues was measured. Result: Simulations showed that CNR is primarly determined by the TR, followed by the number of the first partition encoding steps in MP2RAGE. Keeping TR constant, a smaller number of partition encoding steps increases the achievable maximal CNR. In-vivo 2D MP2RAGE improves CNR between white and gray matters by 9% when compared to 1D accelerated MP2RAGE with identical voxel size. Conclusion: We presented 2D accelated MP2RAGE at 7 T with the increased flip angle. We show that this leads to CNR improvement, and consequently a reduction of scan time to be compared to 1D accelerated MP2RAGE.
Original language | English |
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Pages (from-to) | 779-784 |
Number of pages | 6 |
Journal | Magnetic Resonance Imaging |
Volume | 34 |
Issue number | 6 |
DOIs | |
State | Published - 1 Jul 2016 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Inc.
Keywords
- 2D acceleration
- 7 T
- MP2RAGE
- MPRAGE
- SPIRiT
- Ultra-high filed