TY - JOUR
T1 - Clinicopathologic characteristics of pregnancy-associated breast cancer
T2 - Results of analysis of a nationwide breast cancer registry database
AU - Kim, Yun Gyoung
AU - Jeon, Ye Won
AU - Ko, Byung Kyun
AU - Sohn, Guiyun
AU - Kim, Eun Kyu
AU - Moon, Byung In
AU - Youn, Hyun Jo
AU - Kim, Hyun Ah
N1 - Funding Information:
This study was supported by the Korean Breast Cancer Society.
Funding Information:
This article was supported by the Korean Breast Cancer Society. The contributors and their affiliations are as follows: Sei Hyun Ahn, Asan Medical Center; Dong-Young Noh, Seoul National University Hospital; Seok Jin Nam, Samsung Medical Center; Eun Sook Lee, National Cancer Center; Byeong-Woo Park, Yonsei University Severance Hospital; Woo Chul Noh, Korea Cancer Center Hospital; Jung Han Yoon, Chonnam National University Hwasun Hospital; Soo Jung Lee, Yeungnam University Medical Center; Eun Kyu Lee, Seoul National University Bundang Hospital; Joon Jeong, Yonsei University Gangnam Severance Hospital; Sehwan Han, Ajou University School of Medicine; Ho Yong Park, Kyung-pook National University Medical Center; Nam-Sun Paik, Ewha Womans University Mokdong Hospital; Young Tae Bae, Pusan National University Hospital; Hyouk Jin Lee, Saegyaero Hospital; Heung Kyu Park, Gachon University Gil Hospital; Seung Sang Ko, Dankook University Cheil General Hospital and Women’s Healthcare Center; Byung Joo Song, The Catholic University of Korea Bucheon St. Mary’s Hospital; Young Jin Suh, The Catholic University of Korea St. Vincent’s Hospital; Sung Hoo Jung, Chonbuk National University Hospital; Se Heon Cho, Dong-A University Hospital; Sei Joong Kim, Inha University Hospital; Se Jeong Oh, The Catholic University of Korea Incheon St. Mary’s Hospital; Byung Kyun Ko, Ulsan University Hospital; Ku Sang Kim, Ulsan City Hospital; Chan-heun Park, Sungkyunkwan University Kangbuk Samsung Hospital; Jong-Min Baek, The Catholic University of Korea Yeuido St. Mary’s Hospital; Ki-Tae Hwang, Seoul National University Boramae Medical Center; Je Ryong Kim, Chung-nam National University Hospital; Jeoung Won Bae, Korea University Anam Hospital; Jeong-Soo Kim, The Catholic University of Korea Uijeongbu St. Mary’s Hospital; Sun Hee Kang, Keimyung University School of Medicine Dongsan Medical Center; Geumhee Gwak, Inje University Sanggye Paik Hospital; Jee Hyun Lee, Soonchunhyang University Seoul Hospital; Tae Hyun Kim, Inje University Busan Paik Hospital; Myung-chul Chang, Dankook University Hospital; Sung Yong Kim, Soonchunhyang University College of Medicine Cheonan Hospital; Jung Sun Lee, Inje University College of Medicine Haeundae Paik Hospital; Jeong-Yoon Song, Kyung Hee University Hospital at Gangdong; Hai Lin Park, Gangnam CHA University Hospital; Sun Young Min, Kyung Hee University Medical Center; Jung-Hyun Yang, Konkuk University Medical Center; Sung Hwan Park, Catholic University of Daegu Hospital; Woo-Chan Park, The Catholic University of Korea Seoul St. Mary’s Hospital; Lee Su Kim, Hallym University Hallym Sacred Heart Hospital; Dong Won Ryu, Kosin University Gospel Hospital; Kweon Cheon Kim, Chosun University Hospital; Min Sung Chung, Hanyang University Seoul Hospital; Hee Boong Park, Park Hee Boong Surgical Clinic; Cheol Wan Lim, Soonchunhyang University Bucheon Hospital; Un Jong Choi, Wonkwang University Hospital; Beom Seok Kwak, Dongguk University Ilsan Hospital; Young Sam Park, Presbyterian Medical Center; Hyuk Jai Shin, Myongji Hospital; Young Jin Choi, Chungbuk National University Hospital; Doyil Kim, MizMedi Hospital; Airi Han, Yonsei University Wonju Severance Christian Hospital; Jong Hyun Koh, Cheongju St. Mary’s Hospital; Sangyong Choi, Gwangmyeong Sungae Hospital; Daesung Yoon, Konyang University Hospital; Soo Youn Choi, Hallym University Kangdong Sacred Heart Hospital; Shin Hee Chul, Chung-Ang University Hospital; Jae Il Kim, Inje University Ilsan Paik Hospital; Jae Hyuck Choi, Jeju National University Hospital; Jin Woo Ryu, Chungmu General Hospital; Chang Dae Ko, Dr. Ko’s Breast Clinic; Il Kyun Lee, The Catholic Kwandong University International St. Mary’s Hospital; Dong Seok Lee, Bun Hong Hospital; Seunghye Choi, The Catholic University of Korea St. Paul’s Hospital; Youn Ki Min, Cheju Halla General Hospital; Young San Jeon, Goo Hospital; Eun-Hwa Park, Ulsan University Gangneung Asan Hospital.
Publisher Copyright:
© 2017 Korean Breast Cancer Society. All rights reserved.
PY - 2017/9
Y1 - 2017/9
N2 - Purpose: This study aimed to evaluate the clinicopathological characteristics of pregnancy-associated breast cancer (PABC) in comparison with non-pregnancy associated breast cancer (non-PABC). Methods: A total of 344 eligible patients with PABC were identified in the Korean Breast Cancer Society Registry database. PABC was defined as ductal carcinoma in situ, invasive ductal carcinoma, or invasive lobular carcinoma diagnosed during pregnancy or within 1 year after the birth of a child. Patients with non-PABC were selected from the same database using a 1:2 matching method. The matching variables were operation, age, and initial stage. Results: Patients with PABC had significantly lower survival rates than patient with non-PABC (10-year survival rate: PABC, 76.4%; non-PABC, 85.1%; p= 0.011). PABC patients had higher histologic grade and were more frequently hormone receptor negative than non-PABC patients. Being overweight (body mass index [BMI], ≥23 kg/m2), early menarche (≤13 years), late age at first childbirth (≥30 years), and a family history of breast cancer were more common in the PABC group than in the non-PABC group. Multivariate analysis showed the following factors to be significantly associated with PABC (vs. non-PABC): early menarche (odds ratio [OR], 2.165; 95% confidence interval [CI], 1.566−2.994; p<0.001), late age at first childbirth (OR, 2.446; 95% CI, 1.722−3.473; p< 0.001), and being overweight (OR, 1.389; 95% CI, 1.007−1.917; p= 0.045). Conclusion: Early menarche, late age at first childbirth, and BMI ≥ 23 kg/m2 were more associated with PABC than non-PABC.
AB - Purpose: This study aimed to evaluate the clinicopathological characteristics of pregnancy-associated breast cancer (PABC) in comparison with non-pregnancy associated breast cancer (non-PABC). Methods: A total of 344 eligible patients with PABC were identified in the Korean Breast Cancer Society Registry database. PABC was defined as ductal carcinoma in situ, invasive ductal carcinoma, or invasive lobular carcinoma diagnosed during pregnancy or within 1 year after the birth of a child. Patients with non-PABC were selected from the same database using a 1:2 matching method. The matching variables were operation, age, and initial stage. Results: Patients with PABC had significantly lower survival rates than patient with non-PABC (10-year survival rate: PABC, 76.4%; non-PABC, 85.1%; p= 0.011). PABC patients had higher histologic grade and were more frequently hormone receptor negative than non-PABC patients. Being overweight (body mass index [BMI], ≥23 kg/m2), early menarche (≤13 years), late age at first childbirth (≥30 years), and a family history of breast cancer were more common in the PABC group than in the non-PABC group. Multivariate analysis showed the following factors to be significantly associated with PABC (vs. non-PABC): early menarche (odds ratio [OR], 2.165; 95% confidence interval [CI], 1.566−2.994; p<0.001), late age at first childbirth (OR, 2.446; 95% CI, 1.722−3.473; p< 0.001), and being overweight (OR, 1.389; 95% CI, 1.007−1.917; p= 0.045). Conclusion: Early menarche, late age at first childbirth, and BMI ≥ 23 kg/m2 were more associated with PABC than non-PABC.
KW - Breast neoplasms
KW - Pregnancy
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85030642640&partnerID=8YFLogxK
U2 - 10.4048/jbc.2017.20.3.264
DO - 10.4048/jbc.2017.20.3.264
M3 - Article
AN - SCOPUS:85030642640
VL - 20
SP - 264
EP - 269
JO - Journal of Breast Cancer
JF - Journal of Breast Cancer
SN - 1738-6756
IS - 3
ER -