Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Jae Ri Kim, Kee Taek Jang, Jin Young Jang, Kyungbun Lee, Jung Hoon Kim, Haeryoung Kim, Sun Whe Kim, Wooil Kwon, Dong Wook Choi, Jin Seok Heo, In Woong Han, Shin Hwang, Wan Joon Kim, Seung Mo Hong, Dong Sik Kim, Young Dong Yu, Joo Young Kim, Yang Won Nah, Hyung Woo Park, Hye Jeong ChoiHo Seong Han, Yoo Seok Yoon, Sang Jae Park, Eun Kyung Hong, Hyung Il Seo, Do Youn Park, Koo Jeong Kang, Yu Na Kang, Hee Chul Yu, Woo Sung Moon, Chang Sup Lim, Jeong Mo Bae, Sungho Jo, Wonae Lee, Young Hun Roh, Jin Sook Jeong, Chi Young Jeong, Jong Sil Lee, In Sang Song, Kyung Hee Kim, Ho Gak Kim, Chang Ho Cho, Sun Hyung Joo, Kyu Yeoun Won, Hong Jin Kim, Joon Hyuk Choi, Chong Woo Chu, Jung Hee Lee, Il Young Park, Heejeong Lee, Seung Eun Lee, Hee Sung Kim, Hyeon Kook Lee, Min Sun Cho, Hongbeom Kim, Kang Min Han

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the “Jang & Kim's modified anatomical classification,” 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010–4.433]). Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.

Original languageEnglish
Pages (from-to)1139-1148
Number of pages10
Issue number8
StatePublished - Aug 2020

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© 2019 International Hepato-Pancreato-Biliary Association Inc.


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