TY - JOUR
T1 - Clinical utility of FDG uptake within reticuloendothelial system on F-18 FDG PET/ CT for prediction of tumor recurrence in breast cancer
AU - Bang, Ji In
AU - Yoon, Hai Jeon
AU - Kim, Bom Sahn
N1 - Funding Information:
This research was supported by the NRF funded by the Ministry of Science and ICT (grant number, NRF- 2018R1D1A1B07045321) and by Ewha Womans University (2018-0722-001-1 and 2018-0768-001-1). The funders had no role in study design, data collection and analysis, or preparation of the manuscript.
Publisher Copyright:
© 2018 Bang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/12
Y1 - 2018/12
N2 - Background The aim of this study was to investigate the metabolism of the spleen, bone marrow (BM), and liver from preoperative F-18 FDG PET/CT scans for the prediction of recurrence in breast cancer. Methods We retrospectively included 153 patients diagnosed with invasive ductal carcinoma (IDC) of the breast who underwent preoperative F-18 FDG PET/CT scan and a curative operation. The mean standardized uptake value (SUV mean ) of the spleen, liver, and BM and maximum SUV (SUV max ) of primary tumors were measured. The relationships between spleen, BM, and liver metabolism and clinicopathologic parameters were evaluated, and possible prognostic parameters predicting recurrence were assessed using disease-free survival (DFS). Results Spleen SUV mean was significantly correlated with primary tumor SUV max , pathologic T (pT) stage, and histologic grade of primary tumor. BM SUV mean also showed a positive correlation with primary tumor SUV max . Spleen SUV mean were significantly associated with recurrence from binary logistic regression analysis (P = 0.004). Spleen, BM, liver, and primary tumor SUVs were all significant prognostic factors for DFS in univariate Cox regression analysis (all P<0.024). Among all PET parameters analyzed, spleen SUV mean 2.21 (P = 0.032) was in the multivariable analysis the powerful poor prognostic factor predicting DFS that was independent of other clinicopathological features like T stage (pT >2; P = 0.009) and estrogen receptor (ER) status (ER negativity; P = 0.001). Conclusion Splenic metabolism together with pT stage and ER status was an independent prognostic factor for predicting recurrence in breast cancer. Metabolic activity of reticuloendothelial system such as spleen, liver or BM on preoperative F-18 FDG PET/CT can be a meritorious imaging factor for discriminating patients with IDC that require adjunctive therapy to prevent recurrence.
AB - Background The aim of this study was to investigate the metabolism of the spleen, bone marrow (BM), and liver from preoperative F-18 FDG PET/CT scans for the prediction of recurrence in breast cancer. Methods We retrospectively included 153 patients diagnosed with invasive ductal carcinoma (IDC) of the breast who underwent preoperative F-18 FDG PET/CT scan and a curative operation. The mean standardized uptake value (SUV mean ) of the spleen, liver, and BM and maximum SUV (SUV max ) of primary tumors were measured. The relationships between spleen, BM, and liver metabolism and clinicopathologic parameters were evaluated, and possible prognostic parameters predicting recurrence were assessed using disease-free survival (DFS). Results Spleen SUV mean was significantly correlated with primary tumor SUV max , pathologic T (pT) stage, and histologic grade of primary tumor. BM SUV mean also showed a positive correlation with primary tumor SUV max . Spleen SUV mean were significantly associated with recurrence from binary logistic regression analysis (P = 0.004). Spleen, BM, liver, and primary tumor SUVs were all significant prognostic factors for DFS in univariate Cox regression analysis (all P<0.024). Among all PET parameters analyzed, spleen SUV mean 2.21 (P = 0.032) was in the multivariable analysis the powerful poor prognostic factor predicting DFS that was independent of other clinicopathological features like T stage (pT >2; P = 0.009) and estrogen receptor (ER) status (ER negativity; P = 0.001). Conclusion Splenic metabolism together with pT stage and ER status was an independent prognostic factor for predicting recurrence in breast cancer. Metabolic activity of reticuloendothelial system such as spleen, liver or BM on preoperative F-18 FDG PET/CT can be a meritorious imaging factor for discriminating patients with IDC that require adjunctive therapy to prevent recurrence.
UR - http://www.scopus.com/inward/record.url?scp=85058072562&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0208861
DO - 10.1371/journal.pone.0208861
M3 - Article
C2 - 30532215
AN - SCOPUS:85058072562
SN - 1932-6203
VL - 13
JO - PLoS ONE
JF - PLoS ONE
IS - 12
M1 - e0208861
ER -