Clinical significance of asthma clusters by longitudinal analysis in Korean asthma cohort

So Young Park; Seunghee Baek; Sujeong Kim; Sun Young Yoon; Hyouk Soo Kwon; Yoon Seok Chang; You Sook Cho; An Soo Jang; Jung Won Park; Dong Ho Nahm; Ho Joo Yoon; Sang Heon Cho; Young Joo Cho; Byoung Whui Choi; Hee Bom Moon; Tae Bum Kim

doi:10.1371/journal.pone.0083540

Clinical significance of asthma clusters by longitudinal analysis in Korean asthma cohort

So Young Park, Seunghee Baek, Sujeong Kim, Sun Young Yoon, Hyouk Soo Kwon, Yoon Seok Chang, You Sook Cho, An Soo Jang, Jung Won Park, Dong Ho Nahm, Ho Joo Yoon, Sang Heon Cho, Young Joo Cho, Byoung Whui Choi, Hee Bom Moon, Tae Bum Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: We have previously identified four distinct groups of asthma patients in Korean cohorts using cluster analysis: (A) smoking asthma, (B) severe obstructive asthma, (C) early-onset atopic asthma, and (D) late-onset mild asthma. Methods and Results: A longitudinal analysis of each cluster in a Korean adult asthma cohort was performed to investigate the clinical significance of asthma clusters over 12 months. Cluster A showed relatively high asthma control test (ACT) scores but relatively low FEV₁ scores, despite a high percentage of systemic corticosteroid use. Cluster B had the lowest mean FEV₁, ACT, and the quality of life questionnaire for adult Korean asthmatics (QLQAKA) scores throughout the year, even though the percentage of systemic corticosteroid use was the highest among the four clusters. Cluster C was ranked second in terms of FEV₁, with the second lowest percentage of systemic corticosteroid use, and showed a marked improvement in subjective symptoms over time. Cluster D consistently showed the highest FEV₁, the lowest systemic corticosteroid use, and had high ACT and QLQAKA scores. Conclusion: Our asthma clusters had clinical significance with consistency among clusters over 12 months. These distinctive phenotypes may be useful in classifying asthma in real practice.

Original language	English
Article number	e83540
Journal	PLoS ONE
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0083540
State	Published - 31 Dec 2013

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Park, S. Y., Baek, S., Kim, S., Yoon, S. Y., Kwon, H. S., Chang, Y. S., Cho, Y. S., Jang, A. S., Park, J. W., Nahm, D. H., Yoon, H. J., Cho, S. H., Cho, Y. J., Choi, B. W., Moon, H. B., & Kim, T. B. (2013). Clinical significance of asthma clusters by longitudinal analysis in Korean asthma cohort. PLoS ONE, 8(12), Article e83540. https://doi.org/10.1371/journal.pone.0083540

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title = "Clinical significance of asthma clusters by longitudinal analysis in Korean asthma cohort",

abstract = "Background: We have previously identified four distinct groups of asthma patients in Korean cohorts using cluster analysis: (A) smoking asthma, (B) severe obstructive asthma, (C) early-onset atopic asthma, and (D) late-onset mild asthma. Methods and Results: A longitudinal analysis of each cluster in a Korean adult asthma cohort was performed to investigate the clinical significance of asthma clusters over 12 months. Cluster A showed relatively high asthma control test (ACT) scores but relatively low FEV1 scores, despite a high percentage of systemic corticosteroid use. Cluster B had the lowest mean FEV1, ACT, and the quality of life questionnaire for adult Korean asthmatics (QLQAKA) scores throughout the year, even though the percentage of systemic corticosteroid use was the highest among the four clusters. Cluster C was ranked second in terms of FEV1, with the second lowest percentage of systemic corticosteroid use, and showed a marked improvement in subjective symptoms over time. Cluster D consistently showed the highest FEV1, the lowest systemic corticosteroid use, and had high ACT and QLQAKA scores. Conclusion: Our asthma clusters had clinical significance with consistency among clusters over 12 months. These distinctive phenotypes may be useful in classifying asthma in real practice.",

author = "Park, {So Young} and Seunghee Baek and Sujeong Kim and Yoon, {Sun Young} and Kwon, {Hyouk Soo} and Chang, {Yoon Seok} and Cho, {You Sook} and Jang, {An Soo} and Park, {Jung Won} and Nahm, {Dong Ho} and Yoon, {Ho Joo} and Cho, {Sang Heon} and Cho, {Young Joo} and Choi, {Byoung Whui} and Moon, {Hee Bom} and Kim, {Tae Bum}",

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doi = "10.1371/journal.pone.0083540",

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T1 - Clinical significance of asthma clusters by longitudinal analysis in Korean asthma cohort

AU - Park, So Young

AU - Baek, Seunghee

AU - Kim, Sujeong

AU - Yoon, Sun Young

AU - Kwon, Hyouk Soo

AU - Chang, Yoon Seok

AU - Cho, You Sook

AU - Jang, An Soo

AU - Park, Jung Won

AU - Nahm, Dong Ho

AU - Yoon, Ho Joo

AU - Cho, Sang Heon

AU - Cho, Young Joo

AU - Choi, Byoung Whui

AU - Moon, Hee Bom

AU - Kim, Tae Bum

PY - 2013/12/31

Y1 - 2013/12/31

N2 - Background: We have previously identified four distinct groups of asthma patients in Korean cohorts using cluster analysis: (A) smoking asthma, (B) severe obstructive asthma, (C) early-onset atopic asthma, and (D) late-onset mild asthma. Methods and Results: A longitudinal analysis of each cluster in a Korean adult asthma cohort was performed to investigate the clinical significance of asthma clusters over 12 months. Cluster A showed relatively high asthma control test (ACT) scores but relatively low FEV1 scores, despite a high percentage of systemic corticosteroid use. Cluster B had the lowest mean FEV1, ACT, and the quality of life questionnaire for adult Korean asthmatics (QLQAKA) scores throughout the year, even though the percentage of systemic corticosteroid use was the highest among the four clusters. Cluster C was ranked second in terms of FEV1, with the second lowest percentage of systemic corticosteroid use, and showed a marked improvement in subjective symptoms over time. Cluster D consistently showed the highest FEV1, the lowest systemic corticosteroid use, and had high ACT and QLQAKA scores. Conclusion: Our asthma clusters had clinical significance with consistency among clusters over 12 months. These distinctive phenotypes may be useful in classifying asthma in real practice.

AB - Background: We have previously identified four distinct groups of asthma patients in Korean cohorts using cluster analysis: (A) smoking asthma, (B) severe obstructive asthma, (C) early-onset atopic asthma, and (D) late-onset mild asthma. Methods and Results: A longitudinal analysis of each cluster in a Korean adult asthma cohort was performed to investigate the clinical significance of asthma clusters over 12 months. Cluster A showed relatively high asthma control test (ACT) scores but relatively low FEV1 scores, despite a high percentage of systemic corticosteroid use. Cluster B had the lowest mean FEV1, ACT, and the quality of life questionnaire for adult Korean asthmatics (QLQAKA) scores throughout the year, even though the percentage of systemic corticosteroid use was the highest among the four clusters. Cluster C was ranked second in terms of FEV1, with the second lowest percentage of systemic corticosteroid use, and showed a marked improvement in subjective symptoms over time. Cluster D consistently showed the highest FEV1, the lowest systemic corticosteroid use, and had high ACT and QLQAKA scores. Conclusion: Our asthma clusters had clinical significance with consistency among clusters over 12 months. These distinctive phenotypes may be useful in classifying asthma in real practice.

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Clinical significance of asthma clusters by longitudinal analysis in Korean asthma cohort

Abstract

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