Clinical guidelines for drug-related peptic ulcer, 2020 revised edition

Moon Kyung Joo, Chan Hyuk Park, Joon Sung Kim, Jae Myung Park, Ji Yong Ahn, Bong Eun Lee, Jeong Hoon Lee, Hyo Joon Yang, Yu Kyung Cho, Chang Seok Bang, Beom Jin Kim, Hye Kyung Jung, Byung Wook Kim, Yong Chan Lee

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26 Scopus citations


Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology. However, the previous guidelines were based mainly upon a review of the relevant literature and expert opinion. Therefore, the guidelines need to be revised. We organized a guideline Development Committee for drug-related peptic ulcer under the auspices of the Korean College of Helicobacter and Upper Gastrointestinal Research in 2017 and developed nine statements, including four for NSAIDs, three for aspirin and other antiplatelet agents, and two for anticoagulants through a de novo process founded on evidence-based medicine that included a literature search and a meta-analysis, A consensus was reached through the application of the modified Delphi method. The primary target of these guidelines is adult patients undergoing long-term treatment with NSAIDs, aspirin or other antiplatelet agents and anticoagulants. The revised guidelines reflect the expert consensus and is intended to assist clinicians in the management and prevention of drug-induced peptic ulcer and associated conditions.

Original languageEnglish
Pages (from-to)707-726
Number of pages20
JournalGut and Liver
Issue number6
StatePublished - Nov 2020

Bibliographical note

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© 2020 Editorial Office of Gut and Liver. All rights reserved.


  • Anticoagulants
  • Antiplatelet agent
  • Guideline
  • Non-steroidal anti-inflammatory agents
  • Peptic ulcer


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