Clinical guidelines for drug-related peptic ulcer, 2020 revised edition

Moon Kyung Joo, Chan Hyuk Park, Joon Sung Kim, Jae Myung Park, Ji Yong Ahn, Bong Eun Lee, Jeong Hoon Lee, Hyo Joon Yang, Yu Kyung Cho, Chang Seok Bang, Beom Jin Kim, Hye Kyung Jung, Byung Wook Kim, Yong Chan Lee

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology. However, the previous guidelines were based mainly upon a review of the relevant literature and expert opinion. Therefore, the guidelines need to be revised. We organized a guideline Development Committee for drug-related peptic ulcer under the auspices of the Korean College of Helicobacter and Upper Gastrointestinal Research in 2017 and developed nine statements, including four for NSAIDs, three for aspirin and other antiplatelet agents, and two for anticoagulants through a de novo process founded on evidence-based medicine that included a literature search and a meta-analysis, A consensus was reached through the application of the modified Delphi method. The primary target of these guidelines is adult patients undergoing long-term treatment with NSAIDs, aspirin or other antiplatelet agents and anticoagulants. The revised guidelines reflect the expert consensus and is intended to assist clinicians in the management and prevention of drug-induced peptic ulcer and associated conditions.

Original languageEnglish
Pages (from-to)707-726
Number of pages20
JournalGut and Liver
Issue number6
StatePublished - Nov 2020

Bibliographical note

Funding Information:
These guidelines are being co-published on the Gut and Liver and the Korean Journal of Gastroenterology for facilitated distribution. We would like to express deep thanks to Manager Eun Ju Lee (Medical Library of Korea University), Doctor Myung Han Hyun (Korea University Guro Hospital), Manager Na-Jin Kim and Seung-Jae Lee (Medical Library of Catholic University Songeui Campus), who initially searched the literature by each key clinical question for systematic review; Professor Gwang Ho Baik (Department of Internal Medicine, Hallym University College of Medicine) and Kee Don Choi (Department of Internal Medicine, University of Ulsan College of Medicine), who reviewed the draft manuscript and advised through peer review, and Doctor Hyun Jung Kim (Korea University College of Medicine) and Ein Soon Shin (Research Institute for Healthcare Policy, Korean Medical Association), who gave lectures and advice at the clinic guideline workshop and reviewed and corrected the methodology of the draft recommendations.

Publisher Copyright:
© 2020 Editorial Office of Gut and Liver. All rights reserved.


  • Anticoagulants
  • Antiplatelet agent
  • Guideline
  • Non-steroidal anti-inflammatory agents
  • Peptic ulcer


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