Clinical features of probable cluster headache: A prospective, cross-sectional multicenter study

Jong Hee Sohn, Yun Ju Choi, Byung Kun Kim, Pil Wook Chung, Mi Ji Lee, Min Kyung Chu, Jin Young Ahn, Byung Su Kim, Tae Jin Song, Kyungmi Oh, Kwang Soo Lee, Soo Kyoung Kim, Kwang Yeol Park, Jae Myun Chung, Heui Soo Moon, Chin Sang Chung, Soo Jin Cho, Jeong Wook Park

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16 Scopus citations


Background: Epidemiological data of probable cluster headaches (CH) are scarce in the relevant literature. Here, we sought to assess the prevalence and clinical characteristics of probable CH in comparison with definite CH. Methods: Data used in this study were obtained from the Korean Cluster Headache Registry (KCHR), a prospective, cross-sectional, multicenter headache registry that collected data from consecutive patients diagnosed with CH. Results: In total, 159 patients were enrolled in this study; 20 (12.6%) were diagnosed with probable CH. The most common unfulfilled criterion in patients with probable CH was the duration of attack, which was found in 40% of patients with probable CH. Among clinical characteristics, the number of autonomic symptoms tended to be lower in probable CH than in definite CH (1.7 ± 1.2 vs. 2.4 ± 1.5, p = 0.051) and conjunctival injection and lacrimation showed an increased odds ratio (OR) [OR = 3.03; 95% confidence interval (CI): 1.03-8.33] in definite CH. The groups did not differ with regard to baseline demographic characteristics, disability, impact on life, or treatment response. Conclusions: Probable CH is relatively common among CH disorders, with a clinical impact similar to that of definite CH.

Original languageEnglish
Article number908
JournalFrontiers in Neurology
Issue numberOCT
StatePublished - 26 Oct 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 Sohn, Choi, Kim, Chung, Lee, Chu, Ahn, Kim, Song, Oh, Lee, Kim, Park, Chung, Moon, Chung, Cho and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.


  • Autonomic symptom
  • Cluster headache
  • Definite diagnosis
  • Probable diagnosis
  • Trigeminal autonomic cephalalgia


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