Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study

Min Kyung Chu, Byung Su Kim, Pil Wook Chung, Byung Kun Kim, Mi Ji Lee, Jeong Wook Park, Jin Young Ahn, Dae Woong Bae, Tae Jin Song, Jong Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae Moon Kim, Soo Kyoung Kim, Yun Ju Choi, Jae Myun Chung, Heui Soo Moon, Chin Sang Chung, Kwang Yeol Park, Soo Jin Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Although cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no CAS during their headache attacks. Probable cluster headache (PCH) is a subtype of CH that fulfils all but one criterion of CH. This study aimed to investigate the frequency and clinical features of CH and PCH without CAS in comparison to those with CAS. We analysed data from the Korea Cluster Headache Registry, a prospective multicentre registry involving data from 16 hospitals. Of the 216 participants with CH and 26 with PCH, 19 (8.8%) and 7 (26.9%), respectively, did not have CAS. Participants with CH without CAS exhibited less severe anxiety (General Anxiety Disorder-7 score, median [interquartile range], 2.0 [1.0–6.0] vs 8.0 [3.0–12.0], p = 0.001) and depression (Patient Health Questionnaire-9 score, 3.0 [1.0–7.0] vs 7.0 [3.0–11.0], p = 0.042) than those with CAS. Among participants with PCH, headache intensity was less severe in participants without CAS than in those with CAS (numeric rating scale, 8.0 [7.0–8.0] vs 9.5 [8.0–10.0], p = 0.015). In conclusion, a significant proportion of participants with CH and PCH did not have CAS. Some clinical features of CH and PCH differed based on the presence of CAS.

Original languageEnglish
Article number6916
JournalScientific Reports
Volume11
Issue number1
DOIs
StatePublished - Dec 2021

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