Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study

Min Kyung Chu; Byung Su Kim; Pil Wook Chung; Byung Kun Kim; Mi Ji Lee; Jeong Wook Park; Jin Young Ahn; Dae Woong Bae; Tae Jin Song; Jong Hee Sohn; Kyungmi Oh; Daeyoung Kim; Jae Moon Kim; Soo Kyoung Kim; Yun Ju Choi; Jae Myun Chung; Heui Soo Moon; Chin Sang Chung; Kwang Yeol Park; Soo Jin Cho

doi:10.1038/s41598-021-86408-7

Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study

Min Kyung Chu, Byung Su Kim, Pil Wook Chung, Byung Kun Kim, Mi Ji Lee, Jeong Wook Park, Jin Young Ahn, Dae Woong Bae, Tae Jin Song, Jong Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae Moon Kim, Soo Kyoung Kim, Yun Ju Choi, Jae Myun Chung, Heui Soo Moon, Chin Sang Chung, Kwang Yeol Park, Soo Jin Cho

Department of Neurology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Although cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no CAS during their headache attacks. Probable cluster headache (PCH) is a subtype of CH that fulfils all but one criterion of CH. This study aimed to investigate the frequency and clinical features of CH and PCH without CAS in comparison to those with CAS. We analysed data from the Korea Cluster Headache Registry, a prospective multicentre registry involving data from 16 hospitals. Of the 216 participants with CH and 26 with PCH, 19 (8.8%) and 7 (26.9%), respectively, did not have CAS. Participants with CH without CAS exhibited less severe anxiety (General Anxiety Disorder-7 score, median [interquartile range], 2.0 [1.0–6.0] vs 8.0 [3.0–12.0], p = 0.001) and depression (Patient Health Questionnaire-9 score, 3.0 [1.0–7.0] vs 7.0 [3.0–11.0], p = 0.042) than those with CAS. Among participants with PCH, headache intensity was less severe in participants without CAS than in those with CAS (numeric rating scale, 8.0 [7.0–8.0] vs 9.5 [8.0–10.0], p = 0.015). In conclusion, a significant proportion of participants with CH and PCH did not have CAS. Some clinical features of CH and PCH differed based on the presence of CAS.

Original language	English
Article number	6916
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-86408-7
State	Published - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

Access to Document

10.1038/s41598-021-86408-7

Cite this

Chu, M. K., Kim, B. S., Chung, P. W., Kim, B. K., Lee, M. J., Park, J. W., Ahn, J. Y., Bae, D. W., Song, T. J., Sohn, J. H., Oh, K., Kim, D., Kim, J. M., Kim, S. K., Choi, Y. J., Chung, J. M., Moon, H. S., Chung, C. S., Park, K. Y., & Cho, S. J. (2021). Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study. Scientific Reports, 11(1), Article 6916. https://doi.org/10.1038/s41598-021-86408-7

@article{d63fba12c06c45b9a4890d6eebc2748b,

title = "Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study",

abstract = "Although cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no CAS during their headache attacks. Probable cluster headache (PCH) is a subtype of CH that fulfils all but one criterion of CH. This study aimed to investigate the frequency and clinical features of CH and PCH without CAS in comparison to those with CAS. We analysed data from the Korea Cluster Headache Registry, a prospective multicentre registry involving data from 16 hospitals. Of the 216 participants with CH and 26 with PCH, 19 (8.8%) and 7 (26.9%), respectively, did not have CAS. Participants with CH without CAS exhibited less severe anxiety (General Anxiety Disorder-7 score, median [interquartile range], 2.0 [1.0–6.0] vs 8.0 [3.0–12.0], p = 0.001) and depression (Patient Health Questionnaire-9 score, 3.0 [1.0–7.0] vs 7.0 [3.0–11.0], p = 0.042) than those with CAS. Among participants with PCH, headache intensity was less severe in participants without CAS than in those with CAS (numeric rating scale, 8.0 [7.0–8.0] vs 9.5 [8.0–10.0], p = 0.015). In conclusion, a significant proportion of participants with CH and PCH did not have CAS. Some clinical features of CH and PCH differed based on the presence of CAS.",

author = "Chu, {Min Kyung} and Kim, {Byung Su} and Chung, {Pil Wook} and Kim, {Byung Kun} and Lee, {Mi Ji} and Park, {Jeong Wook} and Ahn, {Jin Young} and Bae, {Dae Woong} and Song, {Tae Jin} and Sohn, {Jong Hee} and Kyungmi Oh and Daeyoung Kim and Kim, {Jae Moon} and Kim, {Soo Kyoung} and Choi, {Yun Ju} and Chung, {Jae Myun} and Moon, {Heui Soo} and Chung, {Chin Sang} and Park, {Kwang Yeol} and Cho, {Soo Jin}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41598-021-86408-7",

language = "English",

volume = "11",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Chu, MK, Kim, BS, Chung, PW, Kim, BK, Lee, MJ, Park, JW, Ahn, JY, Bae, DW, Song, TJ, Sohn, JH, Oh, K, Kim, D, Kim, JM, Kim, SK, Choi, YJ, Chung, JM, Moon, HS, Chung, CS, Park, KY & Cho, SJ 2021, 'Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study', Scientific Reports, vol. 11, no. 1, 6916. https://doi.org/10.1038/s41598-021-86408-7

TY - JOUR

T1 - Clinical features of cluster headache without cranial autonomic symptoms

T2 - results from a prospective multicentre study

AU - Chu, Min Kyung

AU - Kim, Byung Su

AU - Chung, Pil Wook

AU - Kim, Byung Kun

AU - Lee, Mi Ji

AU - Park, Jeong Wook

AU - Ahn, Jin Young

AU - Bae, Dae Woong

AU - Song, Tae Jin

AU - Sohn, Jong Hee

AU - Oh, Kyungmi

AU - Kim, Daeyoung

AU - Kim, Jae Moon

AU - Kim, Soo Kyoung

AU - Choi, Yun Ju

AU - Chung, Jae Myun

AU - Moon, Heui Soo

AU - Chung, Chin Sang

AU - Park, Kwang Yeol

AU - Cho, Soo Jin

PY - 2021/12

Y1 - 2021/12

N2 - Although cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no CAS during their headache attacks. Probable cluster headache (PCH) is a subtype of CH that fulfils all but one criterion of CH. This study aimed to investigate the frequency and clinical features of CH and PCH without CAS in comparison to those with CAS. We analysed data from the Korea Cluster Headache Registry, a prospective multicentre registry involving data from 16 hospitals. Of the 216 participants with CH and 26 with PCH, 19 (8.8%) and 7 (26.9%), respectively, did not have CAS. Participants with CH without CAS exhibited less severe anxiety (General Anxiety Disorder-7 score, median [interquartile range], 2.0 [1.0–6.0] vs 8.0 [3.0–12.0], p = 0.001) and depression (Patient Health Questionnaire-9 score, 3.0 [1.0–7.0] vs 7.0 [3.0–11.0], p = 0.042) than those with CAS. Among participants with PCH, headache intensity was less severe in participants without CAS than in those with CAS (numeric rating scale, 8.0 [7.0–8.0] vs 9.5 [8.0–10.0], p = 0.015). In conclusion, a significant proportion of participants with CH and PCH did not have CAS. Some clinical features of CH and PCH differed based on the presence of CAS.

AB - Although cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no CAS during their headache attacks. Probable cluster headache (PCH) is a subtype of CH that fulfils all but one criterion of CH. This study aimed to investigate the frequency and clinical features of CH and PCH without CAS in comparison to those with CAS. We analysed data from the Korea Cluster Headache Registry, a prospective multicentre registry involving data from 16 hospitals. Of the 216 participants with CH and 26 with PCH, 19 (8.8%) and 7 (26.9%), respectively, did not have CAS. Participants with CH without CAS exhibited less severe anxiety (General Anxiety Disorder-7 score, median [interquartile range], 2.0 [1.0–6.0] vs 8.0 [3.0–12.0], p = 0.001) and depression (Patient Health Questionnaire-9 score, 3.0 [1.0–7.0] vs 7.0 [3.0–11.0], p = 0.042) than those with CAS. Among participants with PCH, headache intensity was less severe in participants without CAS than in those with CAS (numeric rating scale, 8.0 [7.0–8.0] vs 9.5 [8.0–10.0], p = 0.015). In conclusion, a significant proportion of participants with CH and PCH did not have CAS. Some clinical features of CH and PCH differed based on the presence of CAS.

UR - http://www.scopus.com/inward/record.url?scp=85103162278&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-86408-7

DO - 10.1038/s41598-021-86408-7

M3 - Article

C2 - 33767287

AN - SCOPUS:85103162278

SN - 2045-2322

VL - 11

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 6916

ER -

Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this