Clinical differences in Clostridium difficile infection based on age: A multicenter study

Hyung Hun Kim, You Sun Kim, Dong Soo Han, Young Ho Kim, Won Ho Kim, Joo Sung Kim, Hyunsoo Kim, Hyun Soo Kim, Young Sook Park, Hyun Joo Song, Sung Jae Shin, Suk Kyun Yang, Byong Duk Ye, Chang Soo Eun, Kang Moon Lee, Sang Heon Lee, Byung Ik Jang, Sung Ae Jung, Jae Hee Cheon, Chang Hwan ChoiKyuchan Huh

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Advancing age is a well-known risk factor for Clostridium difficile infection (CDI). However, age-specific clinical differences in CDI are uncertain. A retrospective comparative analysis was performed based on age in 1367 patients with CDI in Korea. Most clinical features were similar in the two age groups studied, however malignancy was more common in the older group (age ≥ 65 y) (p < 0.001), while chemotherapy and transplantation were more common in the younger group (age < 65 y) (p < 0.001). Endoscopic examinations were more commonly performed in the older group (p = 0.010), which had a high positive predictive value (88.3%). More patients recovered from CDI without specific antibiotic treatment in the younger group than in the older group (p < 0.001). Although advancing age is an important risk factor for CDI, the clinical features of younger patients are similar to those of the older patient population.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalScandinavian Journal of Infectious Diseases
Issue number1
StatePublished - Jan 2014

Bibliographical note

Funding Information:
Declaration of interest: The authors have no conflicts of interest.This study was supported by the 2012 Inje University research grant.


  • Age
  • Antibiotics
  • Clostridium difficile infection
  • Endoscopy


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