Clinical course of asthma patients with H1N1 infuenza infection and oseltamivir

Min Hye Kim, Woo Jung Song, Min Suk Yang, So Hee Lee, Jae Woo Kwon, Sae Hoon Kim, Hye Ryun Kang, Heung Woo Park, Young Joo Cho, Sang Heon Cho, Kyung Up Min, You Young Kim, Yoon Seok Chang

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4 Scopus citations


BACKGROUND: H1N1 infuenza virus prevailed throughout the world in 2009. However, there are few reports on the clinical features of H1N1 infuenza infection in adult asthma patients. We evaluated the clinical features in asthma patients with H1N1 infuenza infection who took oseltamivir and compared them to those with other upper respiratory infections. METHODS: We reviewed asthma patients over 15 years of age who had visited Seoul National University Hospital and Seoul National University Bundang Hospital for suspected H1N1 infuenza infection from August 2009 to March 2010. Various clinical features such as hospital admission days, respiratory symptoms, basal lung function, and past history was compared between H1N1 infuenza PCR positive and negative groups. RESULTS: a total of 111 asthmatics were enrolled. all patients took oseltamivir. H1N1 rT-PCR was positive in 62 patients (55.9%), negative in 49 patients (44.1%). Wheezing developed more frequently in the H1N1 positive group. (43.5 vs. 16.7%, P=0.044). The rate of acute asthma exacerbations and pneumonia development were higher in the H1N1 positive group (59.7 vs. 51%, P=0.015, 25.0% vs. 0%, P<0.001). The rates for emergency room visit, hospital admissions, intensive care unit admissions, hospital days were not different between the groups. Underlying medical conditions were accompanied more frequently in the H1N1 negative patients (21.6% vs. 30.6%, P=0.002), especially cardiac disease (7.2% vs. 15.3%, P=0.011). CONCLUSIONS: H1N1 infuenza infection may affect the clinical course of asthma combined with more severe manifestations; however, Oseltamivir could have affected the clinical course of H1N1 infected patients and made it milder than expected.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalMinerva Medica
Issue number1
StatePublished - Feb 2018

Bibliographical note

Publisher Copyright:


  • Asthma
  • H1N1 subtype
  • Infuenza A virus
  • Oseltamivir
  • Respiratory tract infections


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