Clinical characteristics of persistent postural-perceptual dizziness and its visual subtype in Korean patients: A multicenter cross-sectional study

Joo Hyun Park, Thanh Tin Nguyen, Sung Hee Kim, Ji Yun Park, Seunghee Na, Eun Ju Jeon, Ji won Seo, Chang Gun Cho, Se Joon Oh, Sung Won Choi, Kwang Dong Choi, Seo Young Choi, Ji Eun Choi, Sung Kwang Hong, Won Ho Chung, Young Sang Cho, Hwan Ho Lee, Yong Hwi An, Kyu Hee Han, Hyung LeeHyun Ah Kim, Ho Yun Lee, Jong Dae Lee, Se A. Lee, Sun Young Oh

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Persistent postural-perceptual dizziness (PPPD) is a chronic functional vestibular disorder for which the Bárány Society has established diagnostic criteria. This nationwide multicenter study aims to investigate the clinical features of individuals with definite PPPD and clinical variant PPPD who do not fully meet the diagnostic criteria, with a particular focus on visual exaggeration. Methods: Between September 2020 and September 2021, a total of 76 individuals with definite PPPD and 109 individuals with clinical variant PPPD who did not meet all three exacerbating factors outlined in Criterion B were recruited from 18 medical centers in South Korea. The study gathered information on demographic factors, clinical manifestations, balance scales, and personality assessments. Results: Comparative analysis between groups with definite PPPD and clinical variant with visual exacerbation revealed no significant differences in sociodemographic characteristics, clinical course, dizziness impact, and specific precipitants. Only disease duration was significantly longer in definite PPPD compared with variant with visual exacerbation. However, the variant without visual exacerbation displayed significantly reduced rates of panic disorder, diminished space-motion discomfort, lesser impact of dizziness, and decreased prevalence of depression when compared with the definitive PPPD. Conclusion: This is the first comprehensive nationwide study examining clinical features of both definite PPPD patients and its clinical variants, considering visual exacerbating factors. Differences in dizziness and personality traits emerged between definite PPPD and its potential variant without visual issues. Our results highlight the possibility of a distinct clinical variant of PPPD influenced by visual dependency.

Original languageEnglish
Article numbere3389
JournalBrain and Behavior
Volume14
Issue number2
DOIs
StatePublished - Feb 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Brain and Behavior published by Wiley Periodicals LLC.

Keywords

  • chronic dizziness
  • persistent postural-perceptual dizziness
  • variant
  • visual subtype

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