Clinical characteristics of patients with tuberculosis-destroyed lung

C. K. Rhee, K. H. Yoo, J. H. Lee, M. J. Park, W. J. Kim, Y. B. Park, Y. I. Hwang, Y. S. Kim, J. Y. Jung, J. Y. Moon, Y. K. Rhee, H. K. Park, J. H. Lim, H. Y. Park, S. W. Lee, Y. H. Kim, S. H. Lee, H. K. Yoon, J. W. Kim, J. S. KimY. K. Kim, Y. M. Oh, Sang Do Lee, H. J. Kim

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72 Scopus citations


SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.

Original languageEnglish
Pages (from-to)67-75+i
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number1
StatePublished - 1 Jan 2013


  • Chronic obstructive pulmonary disease
  • FEV
  • Pulmonary function test
  • Tuberculosis-destroyed lung


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