TY - JOUR
T1 - Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea
AU - Chung, Sook Hee
AU - Park, Sang Un
AU - Cheon, Jae Hee
AU - Kim, Eun Ran
AU - Byeon, Jeong Sik
AU - Ye, Byong Duk
AU - Keum, Bora
AU - Shim, Ki Nam
AU - Jung, Sung Ae
AU - Kim, Jin Oh
AU - Jeon, Seong Ran
AU - Song, Hyun Joo
AU - Moon, Jeong Seop
AU - Chang, Dong Kyung
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/9/22
Y1 - 2015/9/22
N2 - Background: Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. Methods: We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. Results: The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). Conclusion: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.
AB - Background: Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease that is characterized by multiple, recurring small intestinal ulcers with stenosis of unknown causes. The aim of this study was to investigate the clinical characteristics and the treatment outcomes of patients with CMUSE in Korea. Methods: We performed a multicenter study to retrospectively analyze clinical data from 20 patients who suffered from CMUSE between 1984 and 2012. Their clinical characteristics and long-term disease courses were investigated. Results: The most common initial symptom of CMUSE was abdominal pain (14/20, 70 %). Small bowel series (13/20, 65 %), double-balloon enteroscopy (12/20, 60 %), CT enterography (12/20, 60 %), and capsule endoscopy (10/20, 50 %) were used to diagnose CMUSE. The strictures of the patients were located in the jejunum (5/20, 25 %), ileum (7/20, 35 %), and both jejunum and ileum (6/20, 30 %). The number of patients in a state of remission, persistent disease, and relapse at the end of follow-up were 13/20 (65 %), 2/20 (10 %), and 5/20 (25 %), respectively. The median relapse-free survival was of 67.1 months. Seventy-five percent relapse-free survivals for female and male patients were 93 and 9 months, respectively (P = 0.031). Conclusion: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.
KW - Characteristics
KW - Cryptogenic multifocal ulcerous stenosing enteritis
KW - Diagnosis
KW - Treatment outcome
UR - http://www.scopus.com/inward/record.url?scp=84939563668&partnerID=8YFLogxK
U2 - 10.1007/s10620-015-3595-y
DO - 10.1007/s10620-015-3595-y
M3 - Article
C2 - 25708899
AN - SCOPUS:84939563668
SN - 0163-2116
VL - 60
SP - 2740
EP - 2745
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 9
ER -