Clinical Characteristics and Risk Factors of First-Ever Stroke in Young Adults: A Multicenter, Prospective Cohort Study

Yea Jin Jo, Dae Hyun Kim, Min Kyun Sohn, Jongmin Lee, Yong Il Shin, Gyung Jae Oh, Yang Soo Lee, Min Cheol Joo, So Young Lee, Min Keun Song, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Yun Hee Kim, Deog Young Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Stroke in young adults has catastrophic consequences and has increased in prevalence, contrary to the trends of most other diseases. This study aimed to determine the major characteristics and risk factors for stroke in younger adults compared with older adults. From the Korean Stroke Cohort for Functioning and Rehabilitation, 10,584 patients with first-ever stroke between August 2012 and March 2015 were enrolled retrospectively and divided into younger (age ≤ 45) and older groups (age > 45). The clinical characteristics and risk factors of stroke were compared between the younger and older groups. The younger group comprised 915 patients (8.6%). The proportion of hemorrhage strokes in the younger group (42.3%) was significantly higher than in the older group (20.0%) (p < 0.001). Obesity, current smoking, and heavy alcohol consumption were significantly more common risk factors in the younger group than in the older group for all stroke types, whereas hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, and coronary heart disease were significantly more frequent in the older group (both p < 0.001). The major risk factors in the younger group may be lifestyle-related. Therefore, increasing awareness of lifestyle-related risk factors may be necessary to prevent stroke in young adults.

Original languageEnglish
Article number1505
JournalJournal of Personalized Medicine
Issue number9
StatePublished - Sep 2022

Bibliographical note

Funding Information:
This study was supported by the Research Program funded by Korea Disease Control and Prevention Agency (2022-11-006).

Publisher Copyright:
© 2022 by the authors.


  • risk factors
  • stroke
  • young adults


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