Clinical characteristics and long-term prognosis of elderly-onset Crohn’s disease

Eun Mi Song, Nayoung Kim, Sun Ho Lee, Kiju Chang, Sung Wook Hwang, Sang Hyoung Park, Dong Hoon Yang, Jeong Sik Byeon, Seung Jae Myung, Suk Kyun Yang, Byong Duk Ye

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objectives: This study aimed to evaluate the clinical characteristics and clinical course of Asian elderly-onset Crohn’s disease (EOCD) patients in a large well-defined cohort of South Korean IBD patients. Materials and methods: From the Asan inflammatory bowel disease registry, we identified 29 EOCD patients (diagnosed with CD in age of 60 years or over) out of 2989 CD patients (1.0%). After excluding two patients with unclear data, 27 EOCD were matched with 108 young-onset CD (YOCD) and 108 middle age-onset CD (MOCD) for the interval from symptom onset to diagnosis (±3 years) and follow-up duration (±3 years). Results: Females were predominant in the EOCD group (59.3%) compared to MOCD (31.5%) and YOCD (29.6%) groups (p =.012). In EOCD group, terminal ileal location was the most common (63.0%) at diagnosis, whereas ileocolonic location in other groups (57.4% in MOCD and 78.7% in YOCD, respectively) (p <.001). Patients with perianal fistula at CD diagnosis were less common (14.8% in EOCD vs. 28.7% in MOCD vs. 49.1% in YOCD, p <.001). During follow-up, thiopurines were used less frequently in the EOCD group (48.1% in EOCD vs. 87.0% in MOCD vs. 89.8% in YOCD, p <.001), but the risk for intestinal resection was comparable among three groups (p =.583). Conclusions: EOCD may have a better clinical course than MOCD and YOCD, as demonstrated by the similar risk for intestinal resection despite the less frequent use of thiopurines.

Original languageEnglish
Pages (from-to)417-425
Number of pages9
JournalScandinavian Journal of Gastroenterology
Issue number4
StatePublished - 3 Apr 2018

Bibliographical note

Funding Information:
This study was supported by a grant (2010-0774) from the Asan Institute for Life Sciences, Seoul, Korea.

Publisher Copyright:
© 2018 Informa UK Limited, trading as Taylor & Francis Group.


  • aged
  • Crohn disease
  • geriatrics
  • inflammatory bowel disease
  • prognosis


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