Clinical associations between metabolic syndrome and the development of microalbuminuria in Korean men

Jae Hong Ryoo, Hyejin Chun, Hong Soo Lee, Eunkyung Suh, Joong Myung Choi, Min Gi Kim, Ho Cheol Shin, Sung Keun Park, Chang Mo Oh, Taeg Su Ko

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Aims: There have been several studies on the association between metabolic syndrome (MetS) and microalbuminuria. However, none has examined whether MetS is associated with the prospective development of microalbuminuria. Accordingly, we performed a prospective study to evaluate the longitudinal effects of baseline number of MetS traits on the development of microalbuminuria in Korean men. Methods: 1649 Korean men without microalbuminuria in 2005 were included and followed prospectively until 2010 with the endpoint being the development of microalbuminuria. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Microalbuminuria was evaluated by urine albumin creatinine ratio (UACR). Risk estimations for development of microalbuminuria were analyzed according to the number of MetS traits using multivariate adjusted Cox proportional hazards model. Results: During 5611.8 person-years of follow-up (median 3.40. ±. 1.46 years), microalbuminuria developed in 91 (5.5%) participants between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% confidence interval) for development of microalbuminuria comparing 1, 2 and 3-5 MetS traits vs 0 were 2.57 (0.97-6.82), 2.94 (1.09-7.98) and 3.85 (1.37-10.86), respectively. Conclusions: The number of MetS traits independently associated with the future development of microalbuminuria during the 5-year follow-up period, and MetS per se was an independent risk factor for microalbuminuria.

Original languageEnglish
Pages (from-to)407-414
Number of pages8
JournalDiabetes Research and Clinical Practice
Issue number3
StatePublished - 1 Mar 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ireland Ltd.


  • Metabolic syndrome
  • Microalbuminuria
  • Urine albumin creatinine ratio


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