Clinical and microbiological effects of minocycline-loaded microcapsules in adult periodontitis

Hey Ri Yeom, Yoon Jeong Park, Seung Jin Lee, In Cheol Rhyu, Chong Pyoung Chung, Russell J. Nisengard

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


CLINICAL AND MICROBIOLOGICAL EFFECTS of subgingival delivery of 10% minocycline-loaded (MC), bioabsorbable microcapsules were examined in 15 adult periodontitis patients. Patients received oral hygiene instruction 2 weeks prior to the study. At baseline (day 0) all teeth received supragingival scaling (SC); 2 quadrants received no further treatment and 1 quadrant received subgingival scaling and root planing (SRP). In the fourth quadrant, the tooth with the deepest probing sites (at least 1 site ≤ 5 mm) was treated with minocycline microcapsules. The sites were evaluated at baseline and weeks 1, 2, 4, and 6. Clinical indices included bleeding on probing (BOP), probing depths (PD), and attachment loss (AL). Microbiological evaluations included percent morphotypes by phase-contrast microscopy; cultivable anaerobic, aerobic, and black-pigmented Bacteriodes (BPB); and percent Porphyromonas gingivalis, Prevotella intermedia, Eikenella corrodens, and Actinomyces viscosus by indirect immunofluorescence. In the SC=MC group, BOP, PD, and AL were significantly reduced from baseline for weeks 1 to 6. BOP in the SC+MC group was significantly reduced compared to the SRP group rom weeks 2 to 6. In the SC + MC group the percent of spirochetes and motile rods decreased and the percent of cocci increased after 1 week. The increased cocci and decreased motile rods were statistically greater at weeks 4 and 6 in the SC + MC group compared to the SRP group. This study demonstrates that local subgingival delivery of 10% minocycline-loaded microcapsules as an adjunct to scaling results in reduction in the present sites bleeding on probing greater than scaling and root planning alone and induces a microbial response more favorable for periodontal health than scaling and root planing.

Original languageEnglish
Pages (from-to)1102-1109
Number of pages8
JournalJournal of Periodontology
Issue number11
StatePublished - Nov 1997


  • Adult periodontitis
  • Biodegradable microcapsules
  • Minocycline


Dive into the research topics of 'Clinical and microbiological effects of minocycline-loaded microcapsules in adult periodontitis'. Together they form a unique fingerprint.

Cite this