TY - JOUR
T1 - Clinical analysis of drug eruptions among inpatients seeking a consultation with the Department of Dermatology
AU - Lee, Min Young
AU - Byun, Ji Yeon
AU - Choi, Hae Young
AU - Choi, You Won
N1 - Publisher Copyright:
© 2018 Korean Dermatological Association. All Rights Reserved.
PY - 2018/6
Y1 - 2018/6
N2 - Background: Drug eruptions are common in hospitalized patients. Rapid and accurate diagnosis is essential but often difficult. Objective: This study defined the clinical features and causative drugs among inpatients presenting with drug eruptions. Methods: We retrospectively analyzed the clinical and laboratory data of inpatients who sought consultations with the Dermatology Department for a diagnosis of drug eruptions. Results: A total of 228 patients were diagnosed with drug eruptions, and this study included 139 patients. The highest incidence of drug eruptions was observed in patients in their 50s (22.3%). The most common latent period was up to 1 week (57.6%). The most common drug eruptions were exanthematous eruptions (59.7%), acneiform eruptions (10.8%), and urticaria (9.3%). The most common causative drugs were antibiotics (53.2%), followed by anticancer drugs (19.4%), and contrast media (6.5%). Laboratory abnormalities included eosinophilia (15.8%), abnormal liver function tests (7.9%), leukopenia (4.3%), an elevated serum creatinine level (2.2%), and leukocytosis (0.7%). Conclusion: In descending order, the most frequent drug eruptions were exanthematous eruptions, acneiform eruptions, and urticaria, and the most common causative drugs were antibiotics, anticancer agents, and contrast media. Prompt diagnosis and discontinuation of the causative drug are important in this context. Clinicians should be aware of cutaneous adverse drug reactions.
AB - Background: Drug eruptions are common in hospitalized patients. Rapid and accurate diagnosis is essential but often difficult. Objective: This study defined the clinical features and causative drugs among inpatients presenting with drug eruptions. Methods: We retrospectively analyzed the clinical and laboratory data of inpatients who sought consultations with the Dermatology Department for a diagnosis of drug eruptions. Results: A total of 228 patients were diagnosed with drug eruptions, and this study included 139 patients. The highest incidence of drug eruptions was observed in patients in their 50s (22.3%). The most common latent period was up to 1 week (57.6%). The most common drug eruptions were exanthematous eruptions (59.7%), acneiform eruptions (10.8%), and urticaria (9.3%). The most common causative drugs were antibiotics (53.2%), followed by anticancer drugs (19.4%), and contrast media (6.5%). Laboratory abnormalities included eosinophilia (15.8%), abnormal liver function tests (7.9%), leukopenia (4.3%), an elevated serum creatinine level (2.2%), and leukocytosis (0.7%). Conclusion: In descending order, the most frequent drug eruptions were exanthematous eruptions, acneiform eruptions, and urticaria, and the most common causative drugs were antibiotics, anticancer agents, and contrast media. Prompt diagnosis and discontinuation of the causative drug are important in this context. Clinicians should be aware of cutaneous adverse drug reactions.
KW - Cutaneous adverse drug reaction
KW - Dermatological consultation
KW - Drug eruption
KW - Drug rash
UR - http://www.scopus.com/inward/record.url?scp=85051424893&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85051424893
VL - 56
SP - 314
EP - 321
JO - Korean Journal of Dermatology
JF - Korean Journal of Dermatology
SN - 0494-4739
IS - 5
ER -