Cinnamon(Cinnamomum japonicum) subcritical water extract suppresses gut damage induced by dextran sodium sulfate in mouse colitis model

Min Seo Kim, Yong Dae Kim, Seunghee Kang, Oran Kwon, Jae Ho Shin, Ji Yeon Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Inflammatory bowel disease involves the breaking down of tight junctions and triggers leaky gut syndrome. In this study, we evaluated the effect of cinnamon subcritical water extract (CSE) on gut health improvement using a mouse colitis model induced by 5 % dextran sodium sulfate. The mice were treated with varying concentrations of CSE for 21 days and assessed. We examined histopathological changes, mRNA expression of cytokines and tight junction proteins, and alteration of the gut microbiome. CSE treatment improved clinical symptoms. Moreover, myeloperoxidase activity, interleukin (IL)-1β, IL-6, tumor necrosis factor-α protein, and mRNA expression were reduced in the CSE-treated groups. However, CSE increased the mRNA expression of tight junction proteins, such as ZO-1, occludin, mucin-1, mucin-2, and E-cadherin. In addition, CSE altered the microbiome to reduce inflammation. These results suggested that CSE could prevent dextran sodium sulfate sodium-induced colitis and disruption of the intestinal environment.

Original languageEnglish
Article number104775
JournalJournal of Functional Foods
StatePublished - Dec 2021

Bibliographical note

Funding Information:
This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the High Value-added Food Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (Project No. 116012-3) and the National Research Foundation (NRF) of Korea grant funded by the Ministry of Science & ICT (2017R1E1A1A01074320). We express our sincere appreciation for the support.

Publisher Copyright:
© 2021


  • Cinnamon(Cinnamomum japonicum)
  • Colitis
  • Dextran sodium sulfate
  • Inflammation
  • Inflammatory bowel disease
  • Microbiome analysis


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