Chronic pain: Structural and functional changes in brain structures and associated negative affective states

Seoyon Yang, Min Cheol Chang

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

Chronic pain is a condition in which pain progresses from an acute to chronic state and persists beyond the healing process. Chronic pain impairs function and decreases patients’ quality of life. In recent years, efforts have been made to deepen our understanding of chronic pain and to develop better treatments to alleviate chronic pain. In this review, we summarize the results of previous studies, focusing on the mechanisms underlying chronic pain development and the identification of neural areas related to chronic pain. We review the association between chronic pain and negative affective states. Further, we describe the structural and functional changes in brain structures that accompany the chronification of pain and discuss various neurotransmitter families involved. Our review aims to provide guidance for the development of future therapeutic approaches that could be used in the management of chronic pain.

Original languageEnglish
Article number3130
JournalInternational Journal of Molecular Sciences
Volume20
Issue number13
DOIs
StatePublished - 1 Jul 2019

Keywords

  • Central sensitization
  • Chronic pain
  • Corticolimbic system
  • Negative affective state
  • Neurotransmitter

Fingerprint

Dive into the research topics of 'Chronic pain: Structural and functional changes in brain structures and associated negative affective states'. Together they form a unique fingerprint.

Cite this