Chitosan-coated poly(vinyl alcohol) nanofibers for wound dressings

Yun Ok Kang, In Soo Yoon, So Young Lee, Dae Duk Kim, Seung Jin Lee, Won Ho Park, Samuel M. Hudson

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

A PVA nanofibrous matrix was prepared by electrospinning an aqueous 10 wt % PVA solution. The mean diameter of the PVA nanofibers electrospun from the PVA aqueous solution was 240 nm. The water resistance of the as-spun PVA nanofibrous matrix was improved by physically crosslinking the PVA nanofibers by heat treatment at 150°C for 10 min, which were found to be the optimal heat treatment conditions determined from chemical and morphological considerations. In addition, the heat-treated PVA (H-PVA) nanofibrous matrix was coated with a chitosan solution to construct biomimetic nanofibrous wound dressings. The chitosan-coated PVA (C-PVA) nanofibrous matrix showed less hydrophilic and better tensile properties than the H-PVA nanofibrous matrix. The effect of the chitosan coating on open wound healing in a mouse was examined. The C-PVA and H-PVA nanofibrous matrices showed faster wound healing than the control. The histological examination and mechanical stability revealed the C-PVA nanofibrous matrix to be more effective as a wound-healing accelerator in the early stages of wound healing than the H-PVA nanofibrous matrix.

Original languageEnglish
Pages (from-to)568-576
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume92
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Chitosan
  • Coating
  • Electrospinning
  • Nanofiber
  • Poly(vinyl alcohol) (PVA)
  • Wound healing

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