Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy

Ji Hyun Chang; Kyung Hwan Shin; Seung Do Ahn; Hae Jin Park; Eui Kyu Chie; Jin Ho Kim; Su Ssan Kim; Yong Bae Kim; Won Park; Yeon Joo Kim; Hyun Soo Shin; Jin Hee Kim; Sun Young Lee; Kyubo Kim; Kyung Ran Park; Bae Kwon Jeong; Ja Young Kim; Suzy Kim

doi:10.1007/s10549-018-4707-0

Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy

Ji Hyun Chang, Kyung Hwan Shin, Seung Do Ahn, Hae Jin Park, Eui Kyu Chie, Jin Ho Kim, Su Ssan Kim, Yong Bae Kim, Won Park, Yeon Joo Kim, Hyun Soo Shin, Jin Hee Kim, Sun Young Lee, Kyubo Kim, Kyung Ran Park, Bae Kwon Jeong, Ja Young Kim, Suzy Kim

Department of Radiation Oncology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Purpose: In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). Methods: The data from the patients participating in two South Korean multi-institutional studies (KROG 14–22; N = 1842 and KROG 14–23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. Results: The median follow-up time was 72.2 months (range 0.8–125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. Conclusions: The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.

Original language	English
Pages (from-to)	507-512
Number of pages	6
Journal	Breast Cancer Research and Treatment
Volume	169
Issue number	3
DOIs	https://doi.org/10.1007/s10549-018-4707-0
State	Published - 1 Jun 2018

Bibliographical note

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

1–3 positive nodes
Breast cancer
Chest wall irradiation
Chest wall recurrence risk factor
Post-mastectomy radiation therapy

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10.1007/s10549-018-4707-0

Cite this

Chang, J. H., Shin, K. H., Ahn, S. D., Park, H. J., Chie, E. K., Kim, J. H., Kim, S. S., Kim, Y. B., Park, W., Kim, Y. J., Shin, H. S., Kim, J. H., Lee, S. Y., Kim, K., Park, K. R., Jeong, B. K., Kim, J. Y., & Kim, S. (2018). Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy. Breast Cancer Research and Treatment, 169(3), 507-512. https://doi.org/10.1007/s10549-018-4707-0

@article{97139a162ae84a1fa2c265a640ec9183,

title = "Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy",

abstract = "Purpose: In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). Methods: The data from the patients participating in two South Korean multi-institutional studies (KROG 14–22; N = 1842 and KROG 14–23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. Results: The median follow-up time was 72.2 months (range 0.8–125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. Conclusions: The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.",

keywords = "1–3 positive nodes, Breast cancer, Chest wall irradiation, Chest wall recurrence risk factor, Post-mastectomy radiation therapy",

author = "Chang, {Ji Hyun} and Shin, {Kyung Hwan} and Ahn, {Seung Do} and Park, {Hae Jin} and Chie, {Eui Kyu} and Kim, {Jin Ho} and Kim, {Su Ssan} and Kim, {Yong Bae} and Won Park and Kim, {Yeon Joo} and Shin, {Hyun Soo} and Kim, {Jin Hee} and Lee, {Sun Young} and Kyubo Kim and Park, {Kyung Ran} and Jeong, {Bae Kwon} and Kim, {Ja Young} and Suzy Kim",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2018",

month = jun,

day = "1",

doi = "10.1007/s10549-018-4707-0",

language = "English",

volume = "169",

pages = "507--512",

journal = "Breast Cancer Research and Treatment",

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Chang, JH, Shin, KH, Ahn, SD, Park, HJ, Chie, EK, Kim, JH, Kim, SS, Kim, YB, Park, W, Kim, YJ, Shin, HS, Kim, JH, Lee, SY, Kim, K, Park, KR, Jeong, BK, Kim, JY & Kim, S 2018, 'Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy', Breast Cancer Research and Treatment, vol. 169, no. 3, pp. 507-512. https://doi.org/10.1007/s10549-018-4707-0

TY - JOUR

T1 - Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy

AU - Chang, Ji Hyun

AU - Shin, Kyung Hwan

AU - Ahn, Seung Do

AU - Park, Hae Jin

AU - Chie, Eui Kyu

AU - Kim, Jin Ho

AU - Kim, Su Ssan

AU - Kim, Yong Bae

AU - Park, Won

AU - Kim, Yeon Joo

AU - Shin, Hyun Soo

AU - Kim, Jin Hee

AU - Lee, Sun Young

AU - Kim, Kyubo

AU - Park, Kyung Ran

AU - Jeong, Bae Kwon

AU - Kim, Ja Young

AU - Kim, Suzy

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Purpose: In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). Methods: The data from the patients participating in two South Korean multi-institutional studies (KROG 14–22; N = 1842 and KROG 14–23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. Results: The median follow-up time was 72.2 months (range 0.8–125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. Conclusions: The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.

AB - Purpose: In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). Methods: The data from the patients participating in two South Korean multi-institutional studies (KROG 14–22; N = 1842 and KROG 14–23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. Results: The median follow-up time was 72.2 months (range 0.8–125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. Conclusions: The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.

KW - 1–3 positive nodes

KW - Breast cancer

KW - Chest wall irradiation

KW - Chest wall recurrence risk factor

KW - Post-mastectomy radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=85041914011&partnerID=8YFLogxK

U2 - 10.1007/s10549-018-4707-0

DO - 10.1007/s10549-018-4707-0

M3 - Article

C2 - 29435854

AN - SCOPUS:85041914011

SN - 0167-6806

VL - 169

SP - 507

EP - 512

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -

Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy

Abstract

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Keywords

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