Chemical profiles and hypoglycemic activities of mulberry leaf extracts vary with ethanol concentration

Ji Yeon Kim, Hye In Chung, Kyeong Ok Jung, Ji Hyang Wee, Oran Kwon

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15 Scopus citations


Five mulberry leaf extracts (water, 25, 50, 75, and 100% EtOH) were characterized for in vitro hypoglycemic activity and chemical profiles. According to chemical profiles obtained from 15Tesla Fourier transform ion cyclotron resonance mass spectrometry, water extracts contained more 1-deoxynojirimycin (DNJ) and fewer phytochemicals than other extracts. However, water extracts showed the highest inhibitory activity of glucose uptake. The degree of inhibition of α-glucosidase activity was similar for all extracts. The effect of mulberry leaf extracts on the glucose metabolism may be attributed to additional or cooperative effects of DNJ with other phytochemical compounds.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalFood Science and Biotechnology
Issue number5
StatePublished - Oct 2013

Bibliographical note

Funding Information:
Acknowledgments The Bioinformatics and Molecular Design Research Center, Seoul, Korea provided technical support. This project was supported by the Ministry of Knowledge and Economy, Korea (RIS program, Project No. B0009639; and RITD program, Project No. 70004683); and the Ministry of Education, Science, and Technology, Korea (Brain Korea 21, Project No. 2006-0519-4-7).


  • 1-deoxynojirimycin
  • chemical profile
  • glucose uptake
  • mulberry leaf
  • α-glucosidase


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