TY - JOUR
T1 - Characteristics of unexpected protein bands in multiple myeloma patients after autologous stem cell transplantation
AU - Kim, Soo Kyung
AU - Jeong, Tae Dong
AU - Kim, So Young
AU - Lee, Woochang
AU - Chun, Sail
AU - Suh, Cheol Won
AU - Min, Won Ki
PY - 2014/5
Y1 - 2014/5
N2 - Objectives: The aim of this study is to investigate the characteristics of unexpected protein bands (UPBs) in patients with multiple myeloma (MM). Design and methods: Individuals diagnosed with MM (n= 193) were enrolled. Their medical records and IFE patterns were reviewed. Results: Of the patients that underwent ASCT, 54% developed UPBs. The median time for UPB appearance and duration was 1.8 and 5.7. months, respectively. IFE revealed 74.1% of UPBs to be of the immunoglobulin G type and 72.2% to be of the κ-type. At UPB appearance, 42.6% of patients were defined as sCR or CR, and 50.0% of the patients satisfying the CR criteria had an abnormal FLC ratio. Of the patients who developed UPBs, five relapsed. Among these, four patients showed disappearance of the previous IFE oligoclonality and reappearance of the original paraprotein at relapse. Conclusions: Close follow-up of UPBs is critical for evaluating MM therapeutic response and disease progression. The presence of monoclonal bands may indicate relapse of disease, but in the vast majority of cases with UPBs, it does not; instead, it most likely represents a transient phenomenon caused by the immune response.
AB - Objectives: The aim of this study is to investigate the characteristics of unexpected protein bands (UPBs) in patients with multiple myeloma (MM). Design and methods: Individuals diagnosed with MM (n= 193) were enrolled. Their medical records and IFE patterns were reviewed. Results: Of the patients that underwent ASCT, 54% developed UPBs. The median time for UPB appearance and duration was 1.8 and 5.7. months, respectively. IFE revealed 74.1% of UPBs to be of the immunoglobulin G type and 72.2% to be of the κ-type. At UPB appearance, 42.6% of patients were defined as sCR or CR, and 50.0% of the patients satisfying the CR criteria had an abnormal FLC ratio. Of the patients who developed UPBs, five relapsed. Among these, four patients showed disappearance of the previous IFE oligoclonality and reappearance of the original paraprotein at relapse. Conclusions: Close follow-up of UPBs is critical for evaluating MM therapeutic response and disease progression. The presence of monoclonal bands may indicate relapse of disease, but in the vast majority of cases with UPBs, it does not; instead, it most likely represents a transient phenomenon caused by the immune response.
KW - Free light chain ratio
KW - Immunofixation electrophoresis
KW - Multiple myeloma
KW - Unexpected protein band
UR - http://www.scopus.com/inward/record.url?scp=84900297330&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2014.02.015
DO - 10.1016/j.clinbiochem.2014.02.015
M3 - Article
C2 - 24582697
AN - SCOPUS:84900297330
SN - 0009-9120
VL - 47
SP - 588
EP - 592
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 7-8
ER -