Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses

Hyun June Shin; Jae Won Hyun; Su Hyun Kim; Min Su Park; Eun Hee Sohn; Seol Hee Baek; Byung Jo Kim; Kyomin Choi; Jeeyoung Oh; Joong Yang Cho; Ohyun Kwon; Woojun Kim; Jee Eun Kim; Ju Hong Min; Byoung Joon Kim; Sun Young Oh; Jong Seok Bae; Kee Hong Park; Jung Hwan Oh; Sung Yeon Sohn; Myoung Jin Jang; Jung Joon Sung; Ho Jin Kim; Sung Min Kim

doi:10.1016/j.msard.2019.08.004

Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses

Hyun June Shin, Jae Won Hyun, Su Hyun Kim, Min Su Park, Eun Hee Sohn, Seol Hee Baek, Byung Jo Kim, Kyomin Choi, Jeeyoung Oh, Joong Yang Cho, Ohyun Kwon, Woojun Kim, Jee Eun Kim, Ju Hong Min, Byoung Joon Kim, Sun Young Oh, Jong Seok Bae, Kee Hong Park, Jung Hwan Oh, Sung Yeon SohnMyoung Jin Jang, Jung Joon Sung, Ho Jin Kim, Sung Min Kim

Department of Neurology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.

Original language	English
Pages (from-to)	209-214
Number of pages	6
Journal	Multiple Sclerosis and Related Disorders
Volume	35
DOIs	https://doi.org/10.1016/j.msard.2019.08.004
State	Published - Oct 2019

Bibliographical note

Funding Information:
This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea .

Funding Information:
This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea.H.-J. Shin, M.S. Park, E.H. Sohn, S.-H. Baek, Byung-Jo Kim, K. Choi, J. Oh, J.-Y. Cho, O. Kwon, W. Kim, J.E. Kim, J.-H. Min, Byoung Joon Kim, S.-Y. Oh, J.S. Bae, K.H. Park, J.-H. Oh, S.-Y. Sohn, and M.-J. Jang have nothing to disclose. J.-W. Hyun has received a grant from the National Research Foundation of Korea. S.-H. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, Merck Serono, and UCB and received a grant from the National Research Foundation of Korea. S.-M. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Genzyme, Merck Serono, and UCB; received a grant from the National Research Foundation of Korea and the Korea Health Industry Development Institute Research; is an Associated Editor of the Journal of Clinical Neurology; S-M. Kim and Seoul National University Hospital has transferred the technology of flow cytometric AQP4-Ab assay to EONE Laboratory, Korea. H.J. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, HanAll BioPharma, MedImmune, Merck Serono, Novartis, Teva-Handok, and UCB; received a grant from the Ministry of Science, ICT & Future Planning; and accepted research funding from Genzyme, Kael-GemVax, Merck Serono, Teva-Handok, and UCB; serves on a steering committee for MedImmune; is a co-editor for the Multiple Sclerosis Journal – Experimental, Translational, and Clinical, and an associated editor for the Journal of Clinical Neurology.

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

Asian
Epidemiology
MRI
Multiple sclerosis
Oligoclonal band

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.msard.2019.08.004

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Shin, H. J., Hyun, J. W., Kim, S. H., Park, M. S., Sohn, E. H., Baek, S. H., Kim, B. J., Choi, K., Oh, J., Cho, J. Y., Kwon, O., Kim, W., Kim, J. E., Min, J. H., Kim, B. J., Oh, S. Y., Bae, J. S., Park, K. H., Oh, J. H., ... Kim, S. M. (2019). Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses. Multiple Sclerosis and Related Disorders, 35, 209-214. https://doi.org/10.1016/j.msard.2019.08.004

@article{ae4a94bdb25e47f4bc7a5b818873274c,

title = "Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses",

abstract = "Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.",

keywords = "Asian, Epidemiology, MRI, Multiple sclerosis, Oligoclonal band",

author = "Shin, {Hyun June} and Hyun, {Jae Won} and Kim, {Su Hyun} and Park, {Min Su} and Sohn, {Eun Hee} and Baek, {Seol Hee} and Kim, {Byung Jo} and Kyomin Choi and Jeeyoung Oh and Cho, {Joong Yang} and Ohyun Kwon and Woojun Kim and Kim, {Jee Eun} and Min, {Ju Hong} and Kim, {Byoung Joon} and Oh, {Sun Young} and Bae, {Jong Seok} and Park, {Kee Hong} and Oh, {Jung Hwan} and Sohn, {Sung Yeon} and Jang, {Myoung Jin} and Sung, {Jung Joon} and Kim, {Ho Jin} and Kim, {Sung Min}",

note = "Funding Information: This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea . Funding Information: This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea.H.-J. Shin, M.S. Park, E.H. Sohn, S.-H. Baek, Byung-Jo Kim, K. Choi, J. Oh, J.-Y. Cho, O. Kwon, W. Kim, J.E. Kim, J.-H. Min, Byoung Joon Kim, S.-Y. Oh, J.S. Bae, K.H. Park, J.-H. Oh, S.-Y. Sohn, and M.-J. Jang have nothing to disclose. J.-W. Hyun has received a grant from the National Research Foundation of Korea. S.-H. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, Merck Serono, and UCB and received a grant from the National Research Foundation of Korea. S.-M. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Genzyme, Merck Serono, and UCB; received a grant from the National Research Foundation of Korea and the Korea Health Industry Development Institute Research; is an Associated Editor of the Journal of Clinical Neurology; S-M. Kim and Seoul National University Hospital has transferred the technology of flow cytometric AQP4-Ab assay to EONE Laboratory, Korea. H.J. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, HanAll BioPharma, MedImmune, Merck Serono, Novartis, Teva-Handok, and UCB; received a grant from the Ministry of Science, ICT & Future Planning; and accepted research funding from Genzyme, Kael-GemVax, Merck Serono, Teva-Handok, and UCB; serves on a steering committee for MedImmune; is a co-editor for the Multiple Sclerosis Journal – Experimental, Translational, and Clinical, and an associated editor for the Journal of Clinical Neurology. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = oct,

doi = "10.1016/j.msard.2019.08.004",

language = "English",

volume = "35",

pages = "209--214",

journal = "Multiple Sclerosis and Related Disorders",

issn = "2211-0348",

publisher = "Elsevier",

}

Shin, HJ, Hyun, JW, Kim, SH, Park, MS, Sohn, EH, Baek, SH, Kim, BJ, Choi, K, Oh, J, Cho, JY, Kwon, O, Kim, W, Kim, JE, Min, JH, Kim, BJ, Oh, SY, Bae, JS, Park, KH, Oh, JH, Sohn, SY, Jang, MJ, Sung, JJ, Kim, HJ & Kim, SM 2019, 'Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses', Multiple Sclerosis and Related Disorders, vol. 35, pp. 209-214. https://doi.org/10.1016/j.msard.2019.08.004

TY - JOUR

T1 - Changing patterns of multiple sclerosis in Korea

T2 - Toward a more baseline MRI lesions and intrathecal humoral immune responses

AU - Shin, Hyun June

AU - Hyun, Jae Won

AU - Kim, Su Hyun

AU - Park, Min Su

AU - Sohn, Eun Hee

AU - Baek, Seol Hee

AU - Kim, Byung Jo

AU - Choi, Kyomin

AU - Oh, Jeeyoung

AU - Cho, Joong Yang

AU - Kwon, Ohyun

AU - Kim, Woojun

AU - Kim, Jee Eun

AU - Min, Ju Hong

AU - Kim, Byoung Joon

AU - Oh, Sun Young

AU - Bae, Jong Seok

AU - Park, Kee Hong

AU - Oh, Jung Hwan

AU - Sohn, Sung Yeon

AU - Jang, Myoung Jin

AU - Sung, Jung Joon

AU - Kim, Ho Jin

AU - Kim, Sung Min

N1 - Funding Information: This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea . Funding Information: This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea.H.-J. Shin, M.S. Park, E.H. Sohn, S.-H. Baek, Byung-Jo Kim, K. Choi, J. Oh, J.-Y. Cho, O. Kwon, W. Kim, J.E. Kim, J.-H. Min, Byoung Joon Kim, S.-Y. Oh, J.S. Bae, K.H. Park, J.-H. Oh, S.-Y. Sohn, and M.-J. Jang have nothing to disclose. J.-W. Hyun has received a grant from the National Research Foundation of Korea. S.-H. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, Merck Serono, and UCB and received a grant from the National Research Foundation of Korea. S.-M. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Genzyme, Merck Serono, and UCB; received a grant from the National Research Foundation of Korea and the Korea Health Industry Development Institute Research; is an Associated Editor of the Journal of Clinical Neurology; S-M. Kim and Seoul National University Hospital has transferred the technology of flow cytometric AQP4-Ab assay to EONE Laboratory, Korea. H.J. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, HanAll BioPharma, MedImmune, Merck Serono, Novartis, Teva-Handok, and UCB; received a grant from the Ministry of Science, ICT & Future Planning; and accepted research funding from Genzyme, Kael-GemVax, Merck Serono, Teva-Handok, and UCB; serves on a steering committee for MedImmune; is a co-editor for the Multiple Sclerosis Journal – Experimental, Translational, and Clinical, and an associated editor for the Journal of Clinical Neurology. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/10

Y1 - 2019/10

N2 - Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.

AB - Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.

KW - Asian

KW - Epidemiology

KW - MRI

KW - Multiple sclerosis

KW - Oligoclonal band

UR - http://www.scopus.com/inward/record.url?scp=85070237789&partnerID=8YFLogxK

U2 - 10.1016/j.msard.2019.08.004

DO - 10.1016/j.msard.2019.08.004

M3 - Article

C2 - 31401425

AN - SCOPUS:85070237789

SN - 2211-0348

VL - 35

SP - 209

EP - 214

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

ER -

Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses

Abstract

Bibliographical note

Keywords

UN SDGs

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