Abstract
Background: The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset. Methods: Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed. Results: The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset. Conclusions: In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.
Original language | English |
---|---|
Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | Multiple Sclerosis and Related Disorders |
Volume | 35 |
DOIs | |
State | Published - Oct 2019 |
Bibliographical note
Funding Information:This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea .
Funding Information:
This work was partly supported by grant no. HI17C0789 from the Korea Health Industry Development Institute Research fund and also by grant no. 2017r1D1A1B03031490 from the National Research Foundation of Korea.H.-J. Shin, M.S. Park, E.H. Sohn, S.-H. Baek, Byung-Jo Kim, K. Choi, J. Oh, J.-Y. Cho, O. Kwon, W. Kim, J.E. Kim, J.-H. Min, Byoung Joon Kim, S.-Y. Oh, J.S. Bae, K.H. Park, J.-H. Oh, S.-Y. Sohn, and M.-J. Jang have nothing to disclose. J.-W. Hyun has received a grant from the National Research Foundation of Korea. S.-H. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, Merck Serono, and UCB and received a grant from the National Research Foundation of Korea. S.-M. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Genzyme, Merck Serono, and UCB; received a grant from the National Research Foundation of Korea and the Korea Health Industry Development Institute Research; is an Associated Editor of the Journal of Clinical Neurology; S-M. Kim and Seoul National University Hospital has transferred the technology of flow cytometric AQP4-Ab assay to EONE Laboratory, Korea. H.J. Kim has lectured, consulted, and received honoraria from Bayer Schering Pharma, Biogen, Genzyme, HanAll BioPharma, MedImmune, Merck Serono, Novartis, Teva-Handok, and UCB; received a grant from the Ministry of Science, ICT & Future Planning; and accepted research funding from Genzyme, Kael-GemVax, Merck Serono, Teva-Handok, and UCB; serves on a steering committee for MedImmune; is a co-editor for the Multiple Sclerosis Journal – Experimental, Translational, and Clinical, and an associated editor for the Journal of Clinical Neurology.
Publisher Copyright:
© 2019 Elsevier B.V.
Keywords
- Asian
- Epidemiology
- MRI
- Multiple sclerosis
- Oligoclonal band