Changes in subcortical structures in early- versus late-onset Alzheimer's disease

Hanna Cho; Sang Won Seo; Jeong Hun Kim; Changsoo Kim; Byoung Seok Ye; Geon Ha Kim; Young Noh; Hee Jin Kim; Cindy W. Yoon; Joon Kyung Seong; Chang Hun Kim; Sue J. Kang; Juhee Chin; Sung Tae Kim; Kyung Han Lee; Duk L. Na

doi:10.1016/j.neurobiolaging.2013.01.001

Changes in subcortical structures in early- versus late-onset Alzheimer's disease

Hanna Cho, Sang Won Seo, Jeong Hun Kim, Changsoo Kim, Byoung Seok Ye, Geon Ha Kim, Young Noh, Hee Jin Kim, Cindy W. Yoon, Joon Kyung Seong, Chang Hun Kim, Sue J. Kang, Juhee Chin, Sung Tae Kim, Kyung Han Lee, Duk L. Na

Department of Neurology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age.

Original language	English
Pages (from-to)	1740-1747
Number of pages	8
Journal	Neurobiology of Aging
Volume	34
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2013.01.001
State	Published - Jul 2013

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare , Republic of Korea ( A102065 ), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011- 0028333 ), a Samsung Medical Center Clinical Research Development Program grants (CRL- 108011 , and CRS 110-14-1), and the Converging Research Center Program through the Ministry of Education, Science and Technology (2010 K001054 ).

Keywords

Alzheimer's Disease
Amygdala
Basal ganglia
Caudate nucleus
Early onset
Globus pallidus
Hippocampus
Longitudinal study
Onset age
Putamen
Subcortical structure
Thalamus

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@article{ea526367695443a487d629d943a0105c,

title = "Changes in subcortical structures in early- versus late-onset Alzheimer's disease",

abstract = "Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age.",

keywords = "Alzheimer's Disease, Amygdala, Basal ganglia, Caudate nucleus, Early onset, Globus pallidus, Hippocampus, Longitudinal study, Onset age, Putamen, Subcortical structure, Thalamus",

author = "Hanna Cho and Seo, {Sang Won} and Kim, {Jeong Hun} and Changsoo Kim and Ye, {Byoung Seok} and Kim, {Geon Ha} and Young Noh and Kim, {Hee Jin} and Yoon, {Cindy W.} and Seong, {Joon Kyung} and Kim, {Chang Hun} and Kang, {Sue J.} and Juhee Chin and Kim, {Sung Tae} and Lee, {Kyung Han} and Na, {Duk L.}",

note = "Funding Information: This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare , Republic of Korea ( A102065 ), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011- 0028333 ), a Samsung Medical Center Clinical Research Development Program grants (CRL- 108011 , and CRS 110-14-1), and the Converging Research Center Program through the Ministry of Education, Science and Technology (2010 K001054 ). ",

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language = "English",

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T1 - Changes in subcortical structures in early- versus late-onset Alzheimer's disease

AU - Cho, Hanna

AU - Seo, Sang Won

AU - Kim, Jeong Hun

AU - Kim, Changsoo

AU - Ye, Byoung Seok

AU - Kim, Geon Ha

AU - Noh, Young

AU - Kim, Hee Jin

AU - Yoon, Cindy W.

AU - Seong, Joon Kyung

AU - Kim, Chang Hun

AU - Kang, Sue J.

AU - Chin, Juhee

AU - Kim, Sung Tae

AU - Lee, Kyung Han

AU - Na, Duk L.

N1 - Funding Information: This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare , Republic of Korea ( A102065 ), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011- 0028333 ), a Samsung Medical Center Clinical Research Development Program grants (CRL- 108011 , and CRS 110-14-1), and the Converging Research Center Program through the Ministry of Education, Science and Technology (2010 K001054 ).

PY - 2013/7

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N2 - Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age.

AB - Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age.

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KW - Amygdala

KW - Basal ganglia

KW - Caudate nucleus

KW - Early onset

KW - Globus pallidus

KW - Hippocampus

KW - Longitudinal study

KW - Onset age

KW - Putamen

KW - Subcortical structure

KW - Thalamus

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DO - 10.1016/j.neurobiolaging.2013.01.001

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AN - SCOPUS:84875855431

SN - 0197-4580

VL - 34

SP - 1740

EP - 1747

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 7

ER -

Changes in subcortical structures in early- versus late-onset Alzheimer's disease

Abstract

Bibliographical note

Keywords

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