@article{dd047881fb6941cd8b97fbe7320993cd,
title = "Changes in renal function and predictors affecting renal outcome of living kidney donors: a nationwide prospective cohort study",
abstract = "Aim: The safety of donors is an important issue in living donor kidney transplantation. We investigated serial changes in renal function and predictors affecting the renal outcome of living kidney donors. Methods: We obtained the data of 456 kidney donors registered to the Korean Organ Transplantation Registry from 2014 to 2016. The estimated glomerular filtration rate (eGFR) changes according to the development of incident chronic kidney disease (CKD) and factors related to CKD were analysed. CKD was defined as an eGFR <60 ml/min/1.73 m2 or the presence of proteinuria or albuminuria. The change in eGFR over time was analysed using a linear mixed model. Results: At 2 years after kidney donation, 21.7% of the donors (99/456) developed CKD. Annual eGFR changes after nephrectomy were 2.2 ml/min/1.73 m2/year in donors without CKD, and − 0.4 ml/min/1.73 m2/year in donors with CKD. Higher systolic blood pressure was associated with higher risk of CKD (odds ratio [OR] 1.322 per 10 mmHg increment, 95% confidence interval [CI] 1.036–1.686, p =.025). Higher pre-donation eGFR (OR 0.906 per 1 ml/min/1.73 m2 increment, 95% CI 0.876–0.936, p <.001) and higher ratio of eGFR at discharge to pre-donation (OR 0.603 per 0.1 increment, 95% CI 0.426–0.849, p =.004) were related to lower risk of CKD. Conclusion: Kidney donors without incident CKD at 2 years after donation showed gradual increases in eGFR, whereas donors with CKD had relatively constant eGFR. A low ratio of eGFR at discharge after nephrectomy to baseline was a risk factor of CKD.",
keywords = "chronic kidney disease, glomerular filtration rate, kidney transplantation, living donor",
author = "{KOTRY study group} and Yunmi Kim and Kim, {Min Ji} and Lee, {Yu Ho} and Lee, {Jung Pyo} and Lee, {Jeong Hoon} and Jaeseok Yang and Kim, {Myoung Soo} and Taehee Kim and Kang, {Sun Woo} and Kim, {Yeong Hoon} and Kim, {Myoung Soo} and Jaeseok Yang and Kong, {Jin Min} and Kwon, {Oh Jung} and Kim, {Deok Gie} and Jung, {Cheol Woong} and Kim, {Yeong Hoon} and Kim, {Joong Kyung} and Kim, {Chan Duck} and Min, {Ji Won} and Park, {Sung Kwang} and Park, {Yeon Ho} and Park, {Jae Berm} and Park, {Jung Hwan} and Park, {Jong Won} and Ban, {Tae Hyun} and Song, {Sang Heon} and Song, {Seung Hwan} and Shin, {Ho Sik} and Yang, {Chul Woo} and Yoon, {Hye Eun} and Lee, {Kang Wook} and Lee, {Dong Ryeol} and Lee, {Dong Won} and Lee, {Sam Yeol} and Lee, {Sang Ho} and Lee, {Su Hyung} and Lee, {Yu Ho} and Lee, {Jung Pyo} and Lee, {Jeong Hoon} and Jeon, {Jin Seok} and Heungman Jun and Kyunghwan Jeong and Chung, {Ku Yong} and Cho, {Hong Rae} and Ki, {Ju Man} and Chae, {Dong Wan} and Choi, {Soo Jin Na} and Sung Shin and Seungyeup Han",
note = "Funding Information: This study was supported by a research fund from the Korea Centers for Disease Control and Prevention (2014-ER6301-00, 2014-ER6301-01, 2014-ER6301-02, 2017-ER6301-00). This study was sponsored by the Korean Society of Transplantation. The authors appreciate the effort of all staff of the participating centres. We also would like to express our gratitude to Bohyun Kim of Indang Bio Medical Research Institute, Inje University Busan Paik Hospital for providing assistance with the statistical analyses. Funding Information: This study was supported by a research fund from the Korea Centers for Disease Control and Prevention (2014‐ER6301‐00, 2014‐ER6301‐01, 2014‐ER6301‐02, 2017‐ER6301‐00). This study was sponsored by the Korean Society of Transplantation. The authors appreciate the effort of all staff of the participating centres. We also would like to express our gratitude to Bohyun Kim of Indang Bio Medical Research Institute, Inje University Busan Paik Hospital for providing assistance with the statistical analyses. Publisher Copyright: {\textcopyright} 2021 Asian Pacific Society of Nephrology.",
year = "2021",
month = jun,
doi = "10.1111/nep.13880",
language = "English",
volume = "26",
pages = "541--548",
journal = "Nephrology",
issn = "1320-5358",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",
}