TY - JOUR
T1 - Changes in plasma and urine endothelin levels during acute exacerbation of asthma
AU - Chang, J. H.
AU - Tae Rim Shin, Rim Shin
AU - Ga Eun Woo, Eun Woo
AU - Jong Seon Kim, Seon Kim
AU - Eun Soon Hong, Soon Hong
AU - Gi Yeoul Seo, Yeoul Seo
AU - Joo Hyun Cha, Hyun Cha
AU - Mi Seon Kim, Seon Kim
AU - Yeung Seon Kim, Seon Kim
AU - Young Joo Cho, Joo Cho
N1 - Funding Information:
This project was funded in part by the University Hospital Research Grants Program. Additionally, Dr Laurie Shroyer’s participation in this project was funded in part by the Department of Veterans Affairs Cooperative Studies Program. Doctor Samantha MaWhinney thanks the Alschuler, Grossman, and Pines Charitable Fund for contributing to her research.
PY - 1997
Y1 - 1997
N2 - Background: Recent studies have documented increased release of endothelin(ET) during acute attack of asthma. The purpose of this study is to observe the link between plasma level and urinary excretion of each and changes during acute exacerbation. Method: Plasma and 24 hour urine were collected from sixteen asthmatics during acute exacerbation, twice; first day of symptomatic exacerbation and two weeks after treatment. Controls were ten healthy normal subjects. All patients were treated with corticosteroid and beta-2 adrenergic agonist on admission. ET was determined by radioimmunoassay and had 100% cross reactivity with ET-1, 67% with ET-2, 84% with ET-3, and 8% with Big-ET. Results: Plasma ETs were significantly elevated during acute attack of asthma compared with those in remission and controls. However, there was no significant changes in urine ET concentrations or total ET amounts in 24 hour urine during exacerbation up to two weeks. Those levels of urine ET in asthmatics were still higher than controls. ET concentrations in plasma or urine were not correlated with pulmonary functional parameters and hypoxemia. Conclusion: The findings suggests that increased plasma ETs are related with exaggerated release during acute asthma. Urinary ET excretion is increased in asthma. However, urine ET changes during exacerbation should be observed in a larger and longer scale.
AB - Background: Recent studies have documented increased release of endothelin(ET) during acute attack of asthma. The purpose of this study is to observe the link between plasma level and urinary excretion of each and changes during acute exacerbation. Method: Plasma and 24 hour urine were collected from sixteen asthmatics during acute exacerbation, twice; first day of symptomatic exacerbation and two weeks after treatment. Controls were ten healthy normal subjects. All patients were treated with corticosteroid and beta-2 adrenergic agonist on admission. ET was determined by radioimmunoassay and had 100% cross reactivity with ET-1, 67% with ET-2, 84% with ET-3, and 8% with Big-ET. Results: Plasma ETs were significantly elevated during acute attack of asthma compared with those in remission and controls. However, there was no significant changes in urine ET concentrations or total ET amounts in 24 hour urine during exacerbation up to two weeks. Those levels of urine ET in asthmatics were still higher than controls. ET concentrations in plasma or urine were not correlated with pulmonary functional parameters and hypoxemia. Conclusion: The findings suggests that increased plasma ETs are related with exaggerated release during acute asthma. Urinary ET excretion is increased in asthma. However, urine ET changes during exacerbation should be observed in a larger and longer scale.
KW - Asthma
KW - Endothelin
KW - Exacerbation
UR - http://www.scopus.com/inward/record.url?scp=0030776633&partnerID=8YFLogxK
U2 - 10.4046/trd.1997.44.4.844
DO - 10.4046/trd.1997.44.4.844
M3 - Article
AN - SCOPUS:0030776633
SN - 1738-3536
VL - 44
SP - 844
EP - 852
JO - Tuberculosis and Respiratory Diseases
JF - Tuberculosis and Respiratory Diseases
IS - 4
ER -