Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020

Seung Ha Song; Hoan Jong Lee; Eun Song Song; Jong Gyun Ahn; Su Eun Park; Taekjin Lee; Hye Kyung Cho; Jina Lee; Yae Jean Kim; Dae Sun Jo; Jong Hyun Kim; Hyun Mi Kang; Joon Kee Lee; Chun Soo Kim; Dong Hyun Kim; Hwang Min Kim; Jae Hong Choi; Byung Wook Eun; Nam Hee Kim; Eun Young Cho; Yun Kyung Kim; Chi Eun Oh; Kyung Hyo Kim; Sang Hyuk Ma; Hyun Joo Jung; Kun Song Lee; Kwang Nam Kim; Hyunju Lee; Eun Hwa Choi

doi:10.1097/INF.0000000000003714

Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020

Seung Ha Song, Hoan Jong Lee, Eun Song Song, Jong Gyun Ahn, Su Eun Park, Taekjin Lee, Hye Kyung Cho, Jina Lee, Yae Jean Kim, Dae Sun Jo, Jong Hyun Kim, Hyun Mi Kang, Joon Kee Lee, Chun Soo Kim, Dong Hyun Kim, Hwang Min Kim, Jae Hong Choi, Byung Wook Eun, Nam Hee Kim, Eun Young ChoYun Kyung Kim, Chi Eun Oh, Kyung Hyo Kim, Sang Hyuk Ma, Hyun Joo Jung, Kun Song Lee, Kwang Nam Kim, Hyunju Lee, Eun Hwa Choi

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objectives: Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. Methods: A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed. Results: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01). Conclusion: During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.

Original language	English
Pages (from-to)	941-946
Number of pages	6
Journal	Pediatric Infectious Disease Journal
Volume	41
Issue number	12
DOIs	https://doi.org/10.1097/INF.0000000000003714
State	Published - 1 Dec 2022

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© 2022 Lippincott Williams and Wilkins. All rights reserved.

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Song, S. H., Lee, H. J., Song, E. S., Ahn, J. G., Park, S. E., Lee, T., Cho, H. K., Lee, J., Kim, Y. J., Jo, D. S., Kim, J. H., Kang, H. M., Lee, J. K., Kim, C. S., Kim, D. H., Kim, H. M., Choi, J. H., Eun, B. W., Kim, N. H., ... Choi, E. H. (2022). Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020. Pediatric Infectious Disease Journal, 41(12), 941-946. https://doi.org/10.1097/INF.0000000000003714

@article{9cc1f75f5cd84ae5a3e3d51905852310,

title = "Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020",

abstract = "Objectives: Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. Methods: A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed. Results: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01). Conclusion: During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.",

author = "Song, {Seung Ha} and Lee, {Hoan Jong} and Song, {Eun Song} and Ahn, {Jong Gyun} and Park, {Su Eun} and Taekjin Lee and Cho, {Hye Kyung} and Jina Lee and Kim, {Yae Jean} and Jo, {Dae Sun} and Kim, {Jong Hyun} and Kang, {Hyun Mi} and Lee, {Joon Kee} and Kim, {Chun Soo} and Kim, {Dong Hyun} and Kim, {Hwang Min} and Choi, {Jae Hong} and Eun, {Byung Wook} and Kim, {Nam Hee} and Cho, {Eun Young} and Kim, {Yun Kyung} and Oh, {Chi Eun} and Kim, {Kyung Hyo} and Ma, {Sang Hyuk} and Jung, {Hyun Joo} and Lee, {Kun Song} and Kim, {Kwang Nam} and Hyunju Lee and Choi, {Eun Hwa}",

year = "2022",

month = dec,

day = "1",

doi = "10.1097/INF.0000000000003714",

language = "English",

volume = "41",

pages = "941--946",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "12",

}

Song, SH, Lee, HJ, Song, ES, Ahn, JG, Park, SE, Lee, T, Cho, HK, Lee, J, Kim, YJ, Jo, DS, Kim, JH, Kang, HM, Lee, JK, Kim, CS, Kim, DH, Kim, HM, Choi, JH, Eun, BW, Kim, NH, Cho, EY, Kim, YK, Oh, CE, Kim, KH, Ma, SH, Jung, HJ, Lee, KS, Kim, KN, Lee, H & Choi, EH 2022, 'Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020', Pediatric Infectious Disease Journal, vol. 41, no. 12, pp. 941-946. https://doi.org/10.1097/INF.0000000000003714

TY - JOUR

T1 - Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020

AU - Song, Seung Ha

AU - Lee, Hoan Jong

AU - Song, Eun Song

AU - Ahn, Jong Gyun

AU - Park, Su Eun

AU - Lee, Taekjin

AU - Cho, Hye Kyung

AU - Lee, Jina

AU - Kim, Yae Jean

AU - Jo, Dae Sun

AU - Kim, Jong Hyun

AU - Kang, Hyun Mi

AU - Lee, Joon Kee

AU - Kim, Chun Soo

AU - Kim, Dong Hyun

AU - Kim, Hwang Min

AU - Choi, Jae Hong

AU - Eun, Byung Wook

AU - Kim, Nam Hee

AU - Cho, Eun Young

AU - Kim, Yun Kyung

AU - Oh, Chi Eun

AU - Kim, Kyung Hyo

AU - Ma, Sang Hyuk

AU - Jung, Hyun Joo

AU - Lee, Kun Song

AU - Kim, Kwang Nam

AU - Lee, Hyunju

AU - Choi, Eun Hwa

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Objectives: Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. Methods: A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed. Results: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01). Conclusion: During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.

AB - Objectives: Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. Methods: A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed. Results: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01). Conclusion: During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.

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U2 - 10.1097/INF.0000000000003714

DO - 10.1097/INF.0000000000003714

M3 - Article

C2 - 36375095

AN - SCOPUS:85141987868

SN - 0891-3668

VL - 41

SP - 941

EP - 946

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 12

ER -

Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020

Abstract

Bibliographical note

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