Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020

Seung Ha Song, Hoan Jong Lee, Eun Song Song, Jong Gyun Ahn, Su Eun Park, Taekjin Lee, Hye Kyung Cho, Jina Lee, Yae Jean Kim, Dae Sun Jo, Jong Hyun Kim, Hyun Mi Kang, Joon Kee Lee, Chun Soo Kim, Dong Hyun Kim, Hwang Min Kim, Jae Hong Choi, Byung Wook Eun, Nam Hee Kim, Eun Young ChoYun Kyung Kim, Chi Eun Oh, Kyung Hyo Kim, Sang Hyuk Ma, Hyun Joo Jung, Kun Song Lee, Kwang Nam Kim, Hyunju Lee, Eun Hwa Choi

Research output: Contribution to journalArticlepeer-review


Objectives: Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. Methods: A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed. Results: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01). Conclusion: During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.

Original languageEnglish
Pages (from-to)941-946
Number of pages6
JournalPediatric Infectious Disease Journal
Issue number12
StatePublished - 1 Dec 2022

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