Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea

Sun Ah Park, Won Seok Chae, Hyeong Jun Kim, Ho Sik Shin, Saeromi Kim, Ji Young Im, Sang Il Ahn, Kyoung Dae Min, Soo Jae Yim, Byoung Seok Ye, Sang Won Seo, Jee Hyang Jeong, Kyung Won Park, Seong Hye Choi, Duk L. Na

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n71), patients with AD dementia (ADD, n76), and other neurological disorders with cognitive decline (OND, n47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control groups (P<0.001 for all), and between the ADD and OND groups (P<0.001 for all). The areas under the curve in differentiation of ADD from control subjects were 0.97 for Aβ42, 0.93 for total tau (tTau), 0.86 for pTau, and 0.99 for both tTauAβ42 and pTauAβ42 ratios. Our revised cutoff value for Aβ42 was higher than our previous one, whereas the values for the Tau proteins were similar. The tTauAβ42 ratio had the highest accuracy, 97. Our findings highlight the usefulness of CSF AD biomarkers in South Korea, and the necessity of continually testing the reliability of cutoff values.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalAlzheimer Disease and Associated Disorders
Volume31
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Alzheimer disease
  • biomarker
  • cerebrospinal fluid
  • diagnosis

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