Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea

Sun Ah Park; Won Seok Chae; Hyeong Jun Kim; Ho Sik Shin; Saeromi Kim; Ji Young Im; Sang Il Ahn; Kyoung Dae Min; Soo Jae Yim; Byoung Seok Ye; Sang Won Seo; Jee Hyang Jeong; Kyung Won Park; Seong Hye Choi; Duk L. Na

doi:10.1097/WAD.0000000000000184

Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea

Sun Ah Park, Won Seok Chae, Hyeong Jun Kim, Ho Sik Shin, Saeromi Kim, Ji Young Im, Sang Il Ahn, Kyoung Dae Min, Soo Jae Yim, Byoung Seok Ye, Sang Won Seo, Jee Hyang Jeong, Kyung Won Park, Seong Hye Choi, Duk L. Na

Department of Neurology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n71), patients with AD dementia (ADD, n76), and other neurological disorders with cognitive decline (OND, n47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control groups (P<0.001 for all), and between the ADD and OND groups (P<0.001 for all). The areas under the curve in differentiation of ADD from control subjects were 0.97 for Aβ42, 0.93 for total tau (tTau), 0.86 for pTau, and 0.99 for both tTauAβ42 and pTauAβ42 ratios. Our revised cutoff value for Aβ42 was higher than our previous one, whereas the values for the Tau proteins were similar. The tTauAβ42 ratio had the highest accuracy, 97. Our findings highlight the usefulness of CSF AD biomarkers in South Korea, and the necessity of continually testing the reliability of cutoff values.

Original language	English
Pages (from-to)	13-18
Number of pages	6
Journal	Alzheimer Disease and Associated Disorders
Volume	31
Issue number	1
DOIs	https://doi.org/10.1097/WAD.0000000000000184
State	Published - 2017

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).

Keywords

Alzheimer disease
biomarker
cerebrospinal fluid
diagnosis

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10.1097/WAD.0000000000000184

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Park, S. A., Chae, W. S., Kim, H. J., Shin, H. S., Kim, S., Im, J. Y., Ahn, S. I., Min, K. D., Yim, S. J., Ye, B. S., Seo, S. W., Jeong, J. H., Park, K. W., Choi, S. H., & Na, D. L. (2017). Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea. Alzheimer Disease and Associated Disorders, 31(1), 13-18. https://doi.org/10.1097/WAD.0000000000000184

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abstract = "Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n71), patients with AD dementia (ADD, n76), and other neurological disorders with cognitive decline (OND, n47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control groups (P<0.001 for all), and between the ADD and OND groups (P<0.001 for all). The areas under the curve in differentiation of ADD from control subjects were 0.97 for Aβ42, 0.93 for total tau (tTau), 0.86 for pTau, and 0.99 for both tTauAβ42 and pTauAβ42 ratios. Our revised cutoff value for Aβ42 was higher than our previous one, whereas the values for the Tau proteins were similar. The tTauAβ42 ratio had the highest accuracy, 97. Our findings highlight the usefulness of CSF AD biomarkers in South Korea, and the necessity of continually testing the reliability of cutoff values.",

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author = "Park, {Sun Ah} and Chae, {Won Seok} and Kim, {Hyeong Jun} and Shin, {Ho Sik} and Saeromi Kim and Im, {Ji Young} and Ahn, {Sang Il} and Min, {Kyoung Dae} and Yim, {Soo Jae} and Ye, {Byoung Seok} and Seo, {Sang Won} and Jeong, {Jee Hyang} and Park, {Kyung Won} and Choi, {Seong Hye} and Na, {Duk L.}",

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AU - Park, Sun Ah

AU - Chae, Won Seok

AU - Kim, Hyeong Jun

AU - Shin, Ho Sik

AU - Kim, Saeromi

AU - Im, Ji Young

AU - Ahn, Sang Il

AU - Min, Kyoung Dae

AU - Yim, Soo Jae

AU - Ye, Byoung Seok

AU - Seo, Sang Won

AU - Jeong, Jee Hyang

AU - Park, Kyung Won

AU - Choi, Seong Hye

AU - Na, Duk L.

PY - 2017

Y1 - 2017

N2 - Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n71), patients with AD dementia (ADD, n76), and other neurological disorders with cognitive decline (OND, n47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control groups (P<0.001 for all), and between the ADD and OND groups (P<0.001 for all). The areas under the curve in differentiation of ADD from control subjects were 0.97 for Aβ42, 0.93 for total tau (tTau), 0.86 for pTau, and 0.99 for both tTauAβ42 and pTauAβ42 ratios. Our revised cutoff value for Aβ42 was higher than our previous one, whereas the values for the Tau proteins were similar. The tTauAβ42 ratio had the highest accuracy, 97. Our findings highlight the usefulness of CSF AD biomarkers in South Korea, and the necessity of continually testing the reliability of cutoff values.

AB - Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n71), patients with AD dementia (ADD, n76), and other neurological disorders with cognitive decline (OND, n47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control groups (P<0.001 for all), and between the ADD and OND groups (P<0.001 for all). The areas under the curve in differentiation of ADD from control subjects were 0.97 for Aβ42, 0.93 for total tau (tTau), 0.86 for pTau, and 0.99 for both tTauAβ42 and pTauAβ42 ratios. Our revised cutoff value for Aβ42 was higher than our previous one, whereas the values for the Tau proteins were similar. The tTauAβ42 ratio had the highest accuracy, 97. Our findings highlight the usefulness of CSF AD biomarkers in South Korea, and the necessity of continually testing the reliability of cutoff values.

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Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea

Abstract

Bibliographical note

Keywords

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