Cerebral white matter abnormalities in patients with charcot-marie-tooth disease

Mina Lee, Chang Hyun Park, Hwa Kyung Chung, Hyeon Jin Kim, Yunseo Choi, Jeong Hyun Yoo, Young Chul Yoon, Young Bin Hong, Ki Wha Chung, Byung Ok Choi, Hyang Woon Lee

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Here, we report the structural evidence of cerebral white matter abnormalities in Charcot-Marie-Tooth (CMT) patients and the relationship between these abnormalities and clinical disability. Brain diffusion tensor imaging (DTI) was performed in CMT patients with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI-CMT) peripheral neuropathy. Although all patients had normal brain magnetic resonance imaging, all genetic subgroups except CMT1A had abnormal DTI findings indicative of significant cerebral white matter abnormalities: decreased fractional anisotropy and axial diffusivity, and increased radial diffusivity. DTI abnormalities were correlated with clinical disability, suggesting that there is comorbidity of central nervous system damage with peripheral neuropathy in CMT patients. ANN NEUROL 2017;81:147–151.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalAnnals of Neurology
Volume81
Issue number1
DOIs
StatePublished - 1 Jan 2017

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