Cerebellar atrophy in patients with subcortical-type vascular cognitive impairment

Cindy W. Yoon, Sang Won Seo, Jun Sung Park, Ki Chang Kwak, Uicheul Yoon, Mee Kyung Suh, Geon Ha Kim, Ji Soo Shin, Chi Hun Kim, Young Noh, Hanna Cho, Min Jeong Kim, Jong Hun Kim, Jee Hoon Roh, Jong Min Lee, Duk L. Na

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Recent studies suggest that the role of the cerebellum extends into cognitive regulation and that subcortical vascular dementia (SVaD) can result in cerebellar atrophy. However, there has been no evaluation of the cerebellar volume in the preclinical stage of SVaD. We aimed to compare cerebellar volume among patients with amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) and evaluate which factors could have contributed to the cerebellar volume. Participants were composed of 355 patients with aMCI, svMCI, Alzheimer's disease (AD), and SVaD. Cerebellar volumes were measured using automated methods. A direct comparison of the cerebellar volume in SVaD and AD groups showed that the SVaD group had a statistically smaller cerebellar volume than the AD group. Additionally, the svMCI group had a smaller cerebellar volume than the aMCI group, with the number of lacunes (especially in the supratentorial regions) being associated with cerebellar volume. Cerebellar volumes were associated with some neuropsychological tests, digit span backward and ideomotor apraxia. These findings suggest that cerebellar atrophy may be useful in differentiating subtypes of dementia and the cerebellum plays a potential role in cognition.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
Issue number1
StatePublished - Feb 2013

Bibliographical note

Funding Information:
Acknowledgments This study was supported by a grant from the Korean Healthcare Technology R&D Project; Ministry for Health, Welfare and Family Affairs, Republic of Korea (A102065 & A070001); a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; R0A-2007-000-20068-0); and a Samsung Medical Center Clinical Research Development Program grant (CRL-108011 & CRS 110-14-1).


  • Cerebellar atrophy
  • Lacunes
  • Subcortical vascular MCI
  • White matter hyperintensities


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