Ceramide synthases: Reexamining longevity

Joo Won Park, Yael Pewzner-Jung

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


The ceramide synthase (CerS) enzymes catalyze the formation of (dihydro) ceramide, and thereby provide critical complexity to all sphingolipids (SLs) with respect to their acyl chain length. This review summarizes the progress in the field of CerS from the time of their discovery more than a decade ago as Longevity assurance (Lass) genes in yeast, until the recent development of CerS-deficient mouse models. Human hereditary CerS disorders are yet to be discovered. However, the recent findings in CerS mutant animals highlight the important physiological role of these enzymes. The fundamental findings with respect to CerS structure, function, localization, and regulation are discussed, as well as CerS roles in maintaining longevity in vivo.

Original languageEnglish
Title of host publicationSphingolipids
Subtitle of host publicationBasic Science and Drug Development
PublisherSpringer Science and Business Media, LLC
Number of pages19
ISBN (Print)9783709113677
StatePublished - 2013

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325


  • Ceramide synthase (CerS) deficiency
  • Fatty acyl-CoA
  • Mice


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