Cell 'Trap and release' using novel microfluidic 'hydraulic jump' trap

D. Mitra, Y. Park, Y. Choi, H. Patel, B. Pham, J. R. Waldeisen, T. Kang, L. P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Cell 'trap and release' in microfluidic devices is critical for on-chip concentration purposes and dynamic microarrays. However, most existing mechanical trapping modalities lack release capabilities and some employ very complex or abrasive trapping mechanisms. Here we describe a novel cell 'trap and release' device, which employs principles similar to the 'hydraulic jump' phenomenon in nature. This new microfluidic 'hydraulic jump' trap is gentle on cells, allows hydrodynamic control over 'trap and release,' and enables rapid mass transfer of nutrients and analytes. Hence, it provides a new platform to analyze and manipulate living cells in physiological microenvironments.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1595-1597
Number of pages3
StatePublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Cell 'trap and release'
  • Hydraulic jump
  • Microfluidics
  • On-chip sample preparation

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