Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging

Kwangmeyung Kim, Misu Lee, Hyungkyu Park, Jong Ho Kim, Sungwon Kim, Hesson Chung, Kuiwon Choi, In San Kim, Baik L. Seong, Ick Chan Kwon

Research output: Contribution to journalArticlepeer-review

215 Scopus citations


Here, we report for the first time cell-permeable and biocompatible polymeric nanoparticles consisting of a polymer conjugated to a near-infrared (NIR) fluorescence (Cy5.5)-linked effector caspase-specific peptide. The close spatial proximity of the NIR fluorochromes in polymeric nanoparticles results in an autoquenched state, but polymer nanoparticles give rise to strong NIR fluorescence signal under apoptotic cells. Thus, the smart polymeric nanoparticle developed here is an attractive probe for real-time imaging of apoptosis in single cells.

Original languageEnglish
Pages (from-to)3490-3491
Number of pages2
JournalJournal of the American Chemical Society
Issue number11
StatePublished - 22 Mar 2006


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