CD4+ VEGFR1HIGH T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice

Jin Young Shin, Il Hee Yoon, Jong Hyung Lim, Jun Seop Shin, Hye Young Nam, Yong Hee Kim, Hyoung Soo Cho, So Hee Hong, Jung Sik Kim, Won Woo Lee, Chung Gyu Park

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Regulatory T cells (Tregs) are a specialized subpopulation of T cells that control the immune response and thereby maintain immune system homeostasis and tolerance to self-antigens. Many subsets of CD4+ Tregs have been identified, including FOXP3+, Tr1, Th3, and Foxp3neg iT(R)35 cells. In this study, we identified a new subset of CD4+ VEGFR1 high Tregs that have immunosuppressive capacity. CD4+ VEGFR1high T cells, which constitute approximately 1.0% of CD4+ T cells, are hyporesponsive to T-cell antigen receptor stimulation. Surface marker and FoxP3 expression analysis revealed that CD4+ VEGFR1 high T cells are distinct from known Tregs. CD4+ VEGFR1 high T cells suppressed the proliferation of CD4+ CD25 - T cell as efficiently as CD4+ CD25 high natural Tregs in a contact-independent manner. Furthermore, adoptive transfer of CD4+ VEGFR1 + T cells from wild type to RAG-2-deficient C57BL/6 mice inhibited effector T-cell-mediated inflammatory bowel disease. Thus, we report CD4+ VEGFR1 high T cells as a novel subset of Tregs that regulate the inflammatory response in the intestinal tract.

Original languageEnglish
Pages (from-to)592-603
Number of pages12
JournalCellular and Molecular Immunology
Issue number5
StatePublished - 8 Sep 2015

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  • inflammatory bowel disease
  • regulatory T cells
  • suppression
  • vascular endothelial growth factor receptor 1


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