CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs

Jing Jin; In Hyuk Jung; Shin Hye Moon; Sejin Jeon; Se Jin Jeong; Seong Keun Sonn; Seungwoon Seo; Mi Ni Lee; Eun Ju Song; Hyae Yon Kweon; Sinai Kim; Tae Kyeong Kim; Juyang Kim; Hong Rae Cho; Jae Hoon Choi; Byungsuk Kwon; Goo Taeg Oh

doi:10.1016/j.celrep.2020.02.103

CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b⁻CD103⁺ DCs

Jing Jin
, In Hyuk Jung
, Shin Hye Moon
, Sejin Jeon
, Se Jin Jeong
, Seong Keun Sonn
, Seungwoon Seo
, Mi Ni Lee
, Eun Ju Song
, Hyae Yon Kweon
, Sinai Kim
, Tae Kyeong Kim
, Juyang Kim
, Hong Rae Cho
, Jae Hoon Choi
, Byungsuk Kwon
, Goo Taeg Oh

Department of Life Science

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Jin et al. demonstrate that CD137 signaling functions as an immune checkpoint by controlling the survival and function of regulatory intestinal CD11b⁻CD103⁺ dendritic cells to coordinate the balance between regulatory T cells and pathogenic IL-23 during acute colitis.

Original language	English
Pages (from-to)	4124-4136.e5
Journal	Cell Reports
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2020.02.103
State	Published - 24 Mar 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

CD137
Foxp3 Treg
IL-23
RALDH2
T17
acute colitis
immune checkpoint
immune tolerance
regulatory CD11bCD103 DC
retinoic acid

Access to Document

10.1016/j.celrep.2020.02.103

Cite this

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title = "CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs",

abstract = "Jin et al. demonstrate that CD137 signaling functions as an immune checkpoint by controlling the survival and function of regulatory intestinal CD11b−CD103+ dendritic cells to coordinate the balance between regulatory T cells and pathogenic IL-23 during acute colitis.",

keywords = "CD137, Foxp3 Treg, IL-23, RALDH2, T17, acute colitis, immune checkpoint, immune tolerance, regulatory CD11bCD103 DC, retinoic acid",

author = "Jing Jin and Jung, \{In Hyuk\} and Moon, \{Shin Hye\} and Sejin Jeon and Jeong, \{Se Jin\} and Sonn, \{Seong Keun\} and Seungwoon Seo and Lee, \{Mi Ni\} and Song, \{Eun Ju\} and Kweon, \{Hyae Yon\} and Sinai Kim and Kim, \{Tae Kyeong\} and Juyang Kim and Cho, \{Hong Rae\} and Choi, \{Jae Hoon\} and Byungsuk Kwon and Oh, \{Goo Taeg\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = mar,

day = "24",

doi = "10.1016/j.celrep.2020.02.103",

language = "English",

volume = "30",

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T1 - CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs

AU - Jin, Jing

AU - Jung, In Hyuk

AU - Moon, Shin Hye

AU - Jeon, Sejin

AU - Jeong, Se Jin

AU - Sonn, Seong Keun

AU - Seo, Seungwoon

AU - Lee, Mi Ni

AU - Song, Eun Ju

AU - Kweon, Hyae Yon

AU - Kim, Sinai

AU - Kim, Tae Kyeong

AU - Kim, Juyang

AU - Cho, Hong Rae

AU - Choi, Jae Hoon

AU - Kwon, Byungsuk

AU - Oh, Goo Taeg

PY - 2020/3/24

Y1 - 2020/3/24

N2 - Jin et al. demonstrate that CD137 signaling functions as an immune checkpoint by controlling the survival and function of regulatory intestinal CD11b−CD103+ dendritic cells to coordinate the balance between regulatory T cells and pathogenic IL-23 during acute colitis.

AB - Jin et al. demonstrate that CD137 signaling functions as an immune checkpoint by controlling the survival and function of regulatory intestinal CD11b−CD103+ dendritic cells to coordinate the balance between regulatory T cells and pathogenic IL-23 during acute colitis.

KW - CD137

KW - Foxp3 Treg

KW - IL-23

KW - RALDH2

KW - T17

KW - acute colitis

KW - immune checkpoint

KW - immune tolerance

KW - regulatory CD11bCD103 DC

KW - retinoic acid

UR - https://www.scopus.com/pages/publications/85081996013

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DO - 10.1016/j.celrep.2020.02.103

M3 - Article

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AN - SCOPUS:85081996013

SN - 2211-1247

VL - 30

SP - 4124-4136.e5

JO - Cell Reports

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