CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11bCD103+ DCs

Jing Jin, In Hyuk Jung, Shin Hye Moon, Sejin Jeon, Se Jin Jeong, Seong Keun Sonn, Seungwoon Seo, Mi Ni Lee, Eun Ju Song, Hyae Yon Kweon, Sinai Kim, Tae Kyeong Kim, Juyang Kim, Hong Rae Cho, Jae Hoon Choi, Byungsuk Kwon, Goo Taeg Oh

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Jin et al. demonstrate that CD137 signaling functions as an immune checkpoint by controlling the survival and function of regulatory intestinal CD11bCD103+ dendritic cells to coordinate the balance between regulatory T cells and pathogenic IL-23 during acute colitis.

Original languageEnglish
Pages (from-to)4124-4136.e5
JournalCell Reports
Volume30
Issue number12
DOIs
StatePublished - 24 Mar 2020

Keywords

  • CD137
  • Foxp3 Treg
  • IL-23
  • RALDH2
  • T17
  • acute colitis
  • immune checkpoint
  • immune tolerance
  • regulatory CD11bCD103 DC
  • retinoic acid

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