CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs

Jing Jin; In Hyuk Jung; Shin Hye Moon; Sejin Jeon; Se Jin Jeong; Seong Keun Sonn; Seungwoon Seo; Mi Ni Lee; Eun Ju Song; Hyae Yon Kweon; Sinai Kim; Tae Kyeong Kim; Juyang Kim; Hong Rae Cho; Jae Hoon Choi; Byungsuk Kwon; Goo Taeg Oh

doi:10.1016/j.celrep.2020.02.103

CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b⁻CD103⁺ DCs

Jing Jin, In Hyuk Jung, Shin Hye Moon, Sejin Jeon, Se Jin Jeong, Seong Keun Sonn, Seungwoon Seo, Mi Ni Lee, Eun Ju Song, Hyae Yon Kweon, Sinai Kim, Tae Kyeong Kim, Juyang Kim, Hong Rae Cho, Jae Hoon Choi, Byungsuk Kwon, Goo Taeg Oh

Department of Life Science

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Jin et al. demonstrate that CD137 signaling functions as an immune checkpoint by controlling the survival and function of regulatory intestinal CD11b⁻CD103⁺ dendritic cells to coordinate the balance between regulatory T cells and pathogenic IL-23 during acute colitis.

Original language	English
Pages (from-to)	4124-4136.e5
Journal	Cell Reports
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2020.02.103
State	Published - 24 Mar 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

CD137
Foxp3 Treg
IL-23
RALDH2
T17
acute colitis
immune checkpoint
immune tolerance
regulatory CD11bCD103 DC
retinoic acid

Access to Document

10.1016/j.celrep.2020.02.103

Cite this

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title = "CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs",

abstract = "Jin et al. demonstrate that CD137 signaling functions as an immune checkpoint by controlling the survival and function of regulatory intestinal CD11b−CD103+ dendritic cells to coordinate the balance between regulatory T cells and pathogenic IL-23 during acute colitis.",

keywords = "CD137, Foxp3 Treg, IL-23, RALDH2, T17, acute colitis, immune checkpoint, immune tolerance, regulatory CD11bCD103 DC, retinoic acid",

author = "Jing Jin and Jung, {In Hyuk} and Moon, {Shin Hye} and Sejin Jeon and Jeong, {Se Jin} and Sonn, {Seong Keun} and Seungwoon Seo and Lee, {Mi Ni} and Song, {Eun Ju} and Kweon, {Hyae Yon} and Sinai Kim and Kim, {Tae Kyeong} and Juyang Kim and Cho, {Hong Rae} and Choi, {Jae Hoon} and Byungsuk Kwon and Oh, {Goo Taeg}",

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AU - Jin, Jing

AU - Jung, In Hyuk

AU - Moon, Shin Hye

AU - Jeon, Sejin

AU - Jeong, Se Jin

AU - Sonn, Seong Keun

AU - Seo, Seungwoon

AU - Lee, Mi Ni

AU - Song, Eun Ju

AU - Kweon, Hyae Yon

AU - Kim, Sinai

AU - Kim, Tae Kyeong

AU - Kim, Juyang

AU - Cho, Hong Rae

AU - Choi, Jae Hoon

AU - Kwon, Byungsuk

AU - Oh, Goo Taeg

PY - 2020/3/24

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KW - Foxp3 Treg

KW - IL-23

KW - RALDH2

KW - T17

KW - acute colitis

KW - immune checkpoint

KW - immune tolerance

KW - regulatory CD11bCD103 DC

KW - retinoic acid

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